European Heart Journal Advance Access originally published online on April 8, 2005
European Heart Journal 2005 26(22):2375-2380; doi:10.1093/eurheartj/ehi228
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Serum deoxyribonuclease I activity can be used as a sensitive marker for detection of transient myocardial ischaemia induced by percutaneous coronary intervention
1Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
2Division of Cardiology, Gunma Prefecture Cardiovascular Centre, Gunma, Japan
3Department of Legal Medicine, Gunma University Graduate School of Medicine, Gunma, Japan
4Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan
Received 20 October 2004; revised 26 January 2005; accepted 17 February 2005; online publish-ahead-of-print 8 April 2005.
* Corresponding author. Fax: +81 776 61 8149. E-mail address: tyasuda{at}fmsrsa.fukui-med.ac.jp
See page 2349 for the editorial comment on this article (doi:10.1093/eurheartj/ehi599)
Aims Cardiac markers such as troponin T (c-TnT) have proven unsuitable for the detection of early and transient myocardial ischaemia. We recently reported that abrupt elevation of serum deoxyribonuclease I (DNase I) activity in the early stage of acute myocardial infarction could be used as a diagnostic marker. To evaluate whether serum DNase I could be used as a marker of early myocardial ischaemia, we investigated alterations in its levels after transient ischaemia induced during percutaneous coronary intervention (PCI).
Methods and results In 24 consecutive patients with stable angina undergoing elective PCI and 12 patients undergoing coronary angiography (CAG), serum samples were tested for DNase I, creatine kinase isoenzyme MB (CK-MB), and c-TnT before, soon after, and 3 and 12–24 h after completion of the procedures. Serum DNase I activity had risen significantly from baseline by 3 h after PCI in 21 of the 24 PCI patients. The mean per cent difference from baseline in serum DNase I activity 3 h after PCI was 35.9±37.5%. Even among the 16 PCI patients whose levels of CK-MB and c-TnT were within the normal range, 13 showed elevation of serum DNase I activity from baseline after PCI. In the CAG patient group, DNase I activity levels remained unchanged at all times after CAG.
Conclusion Elevation of serum DNase I activity can be used as a sensitive marker for detection of transient myocardial ischaemia.
Key Words: Angioplasty • Ischaemia • Deoxyribonuclease I
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