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European Heart Journal Advance Access originally published online on August 16, 2005
European Heart Journal 2005 26(22):2435-2439; doi:10.1093/eurheartj/ehi440
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Oxidative stress in obstructive sleep apnoea

Anna Svatikova, Robert Wolk, Lilach O. Lerman, Luis A. Juncos, Eddie L. Greene, Joseph P. McConnell and Virend K. Somers*

Mayo Clinic College of Medicine, Rochester, MN 55905, USA

Received 29 March 2005; revised 16 June 2005; accepted 7 July 2005; online publish-ahead-of-print 16 August 2005.

* Corresponding author. Tel: +1 507 255 1144; fax: +1 507 255 7070. E-mail address: somers.virend{at}mayo.edu

Aims Any sustained elevation of oxidative stress in patients with obstructive sleep apnoea (OSA) might help explain their increased risk for cardiovascular diseases. We tested the hypothesis that measures of oxidative stress are increased in otherwise healthy subjects with OSA when compared to closely matched OSA-free control subjects.

Methods and results Plasma indices of oxidative stress and lipid peroxidation [thiobarbituric acid-reactive substances (TBARS), oxidized LDL (oxLDL), isoprostanes] were measured in 41 moderate-severe OSA males without other diseases and in 35 matched controls first before sleep, then after 4 h of untreated OSA, and again in the morning after 4 h of effective treatment with continuous positive airway pressure (CPAP). Plasma levels of oxLDL, TBARS, and isoprostanes in OSA patients (n=34, 26, 17, respectively) were comparable to the controls (n=28, 27, 15 for the three markers, respectively). Neither untreated OSA nor CPAP treatment nor normal sleep affected levels of any of the three measures of oxidative stress. There was no association between the severity of sleep apnoea and any measure of oxidative stress.

Conclusion Otherwise healthy OSA patients, without any other co-morbidities, do not manifest evidence for higher oxidative stress and lipid peroxidation. Thus, oxidative stress and lipid peroxidation do not appear to be key mediators of increased cardiovascular disease in OSA patients.

Key Words: Oxidative stress • oxLDL • TBARS • Isoprostanes • Obstructive sleep apnoea • Cardiovascular diseases


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