European Heart Journal Advance Access originally published online on September 23, 2005
European Heart Journal 2005 26(24):2657-2663; doi:10.1093/eurheartj/ehi504
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Increased arterial wave reflections predict severe cardiovascular events in patients undergoing percutaneous coronary interventions
1Cardiology Department, Klinikum of the Kreuzschwestern, Grieskirchnerstrasse 42, 4600 Wels, Austria
2St Vincents' Clinic, UNSW, Sydney, Australia
3Hermesoft Biostatistics, Graz, Austria
Received 18 March 2005; revised 25 August 2005; accepted 2 September 2005; online publish-ahead-of-print 23 September 2005.
* Corresponding author. Tel: +43 7242 415 2215; fax: +43 7242 415 3992. E-mail address: thomas.weber{at}klinikum-wels.at
See page 2609 for the editorial comment on this article (doi:10.1093/eurheartj/ehi607)
Aims Increased arterial wave reflections are associated with the presence and extent of coronary atherosclerosis and with cardiovascular mortality in selected populations. We prospectively evaluated their prognostic value in the short- and long-term following percutaneous coronary interventions (PCIs).
Methods and results We non-invasively quantified wave reflections [expressed as augmentation index corrected for heart rate of 75 b.p.m. (AIx@75)] using applanation tonometry of the radial artery and a validated transfer function to obtain the corresponding aortic values in 262 patients undergoing PCI. During 2-year follow-up, 61 patients reached the primary endpoint [death, myocardial infarction (MI), and restenosis]. Increasing tertiles of Alx@75 were related to the rate of patients reaching the primary endpoint [15.2, 20 and 35.3%, respectively (P=0.001)], as well as the secondary endpoints total mortality, myocardial infarction and death plus myocardial infarction (RR for the third vs. the first tertile 4.33, 3.25 and 3.46, respectively, P<0.05). In a multivariable Cox-regression model, AIx@75 added prognostic value above and beyond clinical risk factors, angiographic variables, and medications (RR 1.8, 95%CI 1.18–2.76 per increasing AIx@75-tertile, P<0.01).
Conclusion Increased arterial wave reflections are independently associated with an increased risk for severe short- and long-term cardiovascular events in patients undergoing PCI.
Key Words: Wave reflections • Coronary disease • Angioplasty • Arteries • Arteriosclerosis
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in EHJ:
- Wave reflections and cardiovascular epidemiology and therapeutics
- Michel E. Safar
EHJ 2005 26: 2609-2610.[Extract] [Full Text]
This article has been cited by other articles:
|
|
 |
|
  F. Antonini-Canterin, S. Carerj, V. Di Bello, G. Di Salvo, S. La Carrubba, O. Vriz, D. Pavan, A. Balbarini, G. L. Nicolosi, and On behalf of the Research Group of the Italian Soc Arterial stiffness and ventricular stiffness: a couple of diseases or a coupling disease? A review from the cardiologist's point of view Eur J Echocardiogr, September 16, 2008; (2008) jen236v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Nakae, S. Matsuo, T. Matsumoto, K. Mitsunami, and M. Horie Augmentation Index and Pulse Wave Velocity as Indicators of Cardiovascular Stiffness Angiology, August 1, 2008; 59(4): 421 - 426. [Abstract] [PDF]
|
|
|
|
 |
|
 J. E. Sharman, C. M. McEniery, R. Campbell, P. Pusalkar, I. B. Wilkinson, J. S. Coombes, and J. R. Cockcroft Nitric Oxide Does Not Significantly Contribute to Changes in Pulse Pressure Amplification During Light Aerobic Exercise Hypertension, April 1, 2008; 51(4): 856 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shimizu and K. Kario Review: Role of the augmentation index in hypertension Therapeutic Advances in Cardiovascular Disease, February 1, 2008; 2(1): 25 - 35. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Crilly, C. Coch, M. Bruce, H. Clark, and D. Williams Indices of cardiovascular function derived from peripheral pulse wave analysis using radial applanation tonometry: a measurement repeatability study Vascular Medicine, August 1, 2007; 12(3): 189 - 197. [Abstract] [PDF]
|
|
|
|
|
|
E. Agabiti-Rosei, G. Mancia, M. F. O'Rourke, M. J. Roman, M. E. Safar, H. Smulyan, J.-G. Wang, I. B. Wilkinson, B. Williams, and C. Vlachopoulos Central Blood Pressure Measurements and Antihypertensive Therapy: A Consensus Document Hypertension, July 1, 2007; 50(1): 154 - 160. [Full Text] [PDF]
|
|
|
|
|
|
S. Laurent and P. Boutouyrie Recent Advances in Arterial Stiffness and Wave Reflection in Human Hypertension Hypertension, June 1, 2007; 49(6): 1202 - 1206. [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Kullo and A. R. Malik Arterial Ultrasonography and Tonometry as Adjuncts to Cardiovascular Risk Stratification J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1413 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Weber, J. Auer, B. Eber, and M. F. O'Rourke Diastolic Blood Pressure in Coronary Artery Disease Ann Intern Med, January 16, 2007; 146(2): 149 - 149. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schillaci, M. Pirro, M. R. Mannarino, G. Pucci, G. Savarese, S. S. Franklin, and E. Mannarino Relation Between Renal Function Within the Normal Range and Central and Peripheral Arterial Stiffness in Hypertension Hypertension, October 1, 2006; 48(4): 616 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Vasan Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations Circulation, May 16, 2006; 113(19): 2335 - 2362. [Full Text] [PDF]
|
|