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European Heart Journal Advance Access originally published online on November 30, 2004
European Heart Journal 2005 26(3):257-262; doi:10.1093/eurheartj/ehi027
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European Heart Journal vol. 26 no. 3 © The European Society of Cardiology 2004; all rights reserved.

Dietary haem iron and coronary heart disease in women

Daphne L. van der A1, Petra H.M. Peeters1, Diederick E. Grobbee1, Joannes J.M. Marx2 and Yvonne T. van der Schouw1,*

1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP Str.6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands
2Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht, The Netherlands

Received 23 March 2004; revised 24 September 2004; accepted 29 September 2004; online publish-ahead-of-print 30 November 2004.

* Corresponding author. Tel: +31 30 250 9360; fax: +31 30 250 5485. E-mail address: y.t.vanderschouw{at}jc.azu.nl

Aims A role for iron in the risk of ischaemic heart disease has been supported by in vitro and in vivo studies. We investigated whether dietary haem iron intake is associated with coronary heart disease (CHD) risk in a large population-based cohort of middle-aged women.

Methods and results We used data of 16 136 women aged 49–70 years at recruitment between 1993 and 1997. Follow-up was complete until 1 January 2000 and 252 newly diagnosed CHD cases were documented. Cox proportional hazards analysis was used to estimate hazard ratios of CHD for quartiles of haem iron intake, adjusted for cardiovascular and nutritional risk factors. We stratified by the presence of additional cardiovascular risk factors, menstrual periods, and antioxidant intake to investigate the possibility of effect modification. High dietary haem iron intake was associated with a 65% increase in CHD risk [hazard ratio (HR)=1.65; 95% confidence interval (CI): 1.07–2.53], after adjustment for cardiovascular and nutritional risk factors. This risk was not modified by additional risk factors, menstruation, or antioxidant intake.

Conclusion The results indicate that middle-aged women with a relatively high haem iron intake have an increased risk of CHD.

Key Words: Coronary disease • Diet • Follow-up studies • Ischaemia • Population


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