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European Heart Journal Advance Access originally published online on November 30, 2004
European Heart Journal 2005 26(4):328-331; doi:10.1093/eurheartj/ehi049
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© The European Society of Cardiology 2004. All rights reserved. For Permissions, please e-mail: journals.permissions{at}oupjournals.org

Acute hyperglycaemia: a ‘new’ risk factor during myocardial infarction

Antonio Ceriello*

Department of Pathology and Medicine, Experimental and Clinical, University of Udine, P. le S. Maria della Misericordia, 33100 Udine, Italy

Received 2 August 2004; revised 6 October 2004; accepted 14 October 2004; online publish-ahead-of-print 30 November 2004.

* Tel: +39 0432 559813; fax: +39 0432 42097. E-mail address: ceriello{at}uniud.it

High admission blood glucose levels after acute myocardial infarction are common and are associated with an increased risk of death in subjects with and without diabetes. In this review, the possible toxic action of acute hyperglycaemia is discussed in order to explain the worse prognosis in subjects with myocardial infarction and concomitant hyperglycaemia. The possible usefulness of intensive insulin treatment is also discussed.

Key Words: Myocardial infarction • Hyperglycaemia • Insulin treatment • Oxidative stress


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