European Heart Journal Advance Access originally published online on January 7, 2005
European Heart Journal 2005 26(5):433-439; doi:10.1093/eurheartj/ehi091
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Pulmonary regurgitation: not a benign lesion
1Adult Congenital Heart Centre, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
2Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital and the National Heart and Lung Institute, Imperial College, London, UK
Received 29 June 2004; revised 2 November 2004; accepted 25 November 2004; online publish-ahead-of-print 7 January 2005.
* Corresponding author. Tel: +44 20 7351 8602; fax: +44 20 7351 8629. E-mail address: m.gatzoulis{at}rbh.nthames.nhs.uk
Pulmonary regurgitation (PR) is a common complication after surgical or percutaneous relief of pulmonary stenosis and following repair of tetralogy of Fallot. Significant PR is usually well tolerated in childhood. However, in the long term, chronic PR has a detrimental effect on right ventricular (RV) function and exercise capacity and leads to an increased risk of arrhythmia and sudden cardiac death (SCD). Recent advances in non-invasive imaging and, in particular, wider availability of cardiovascular magnetic resonance (CMR), have improved the assessment of PR and RV function in these patients. This in turn has facilitated decision making on the optimal timing for elective pulmonary valve replacement (PVR), which should be performed before irreversible RV dysfunction ensues.
Key Words: Pulmonary regurgitation Cardiovascular magnetic resonance Ventricular function
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