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European Heart Journal Advance Access originally published online on October 11, 2005
European Heart Journal 2006 27(1):15-20; doi:10.1093/eurheartj/ehi605
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Diet and inflammation: a link to metabolic and cardiovascular diseases

Katherine Esposito and Dario Giugliano*

Division of Metabolic Diseases, Policlinico Seconda Università di Napoli, University of Naples, Piazza L. Miraglia, 80138 Naples, Italy

Received 30 May 2005; revised 21 September 2005; accepted 29 September 2005; online publish-ahead-of-print 11 October 2005.

* Corresponding author. Fax: +39 081 5665054 E-mail address: dario.giugliano{at}unina2.it

See page 13 for the editorial comment on this article (doi:10.1093/eurheartj/ehi638)

Both epidemiological studies and intervention trials support an important role of diet in reducing the risk of a variety of chronic diseases, including cardiovascular disease, and overall mortality. We discuss available evidence indicating that the generation of a pro-inflammatory milieu might be one mechanism through which unhealthy diets are linked to metabolic and cardiovascular diseases. In practical terms, fully understanding the link between diet and inflammation holds the premise to elucidate the mechanisms by which dietary patterns improve cardiovascular health.

Key Words: Dietary patterns • Inflammation • Endothelial dysfunction • Insulin resistance • Metabolic syndrome


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