European Heart Journal Advance Access originally published online on April 19, 2006
European Heart Journal 2006 27(10):1216-1222; doi:10.1093/eurheartj/ehi859
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Prevalence and impact of worsening renal function in patients hospitalized with decompensated heart failure: results of the prospective outcomes study in heart failure (POSH)
1 National Heart and Lung Institute, Imperial College, London, UK
2 Department of Cardiology, Hôpital Pitié-Salpétrière, Paris, France
3 Biogen Idec Cambridge, MA, USA
Received 23 November 2004; revised 10 March 2006; accepted 17 March 2006; online publish-ahead-of-print 19 April 2006.
* Corresponding author. fax: +44 207 351 8148. E-mail address: m.cowie{at}imperial.ac.uk
Aims To determine the prevalence and risk factors for worsening renal function (WRF) among patients hospitalized for decompensated heart failure (HF) and the association with subsequent re-hospitalization and mortality.
Methods and results We prospectively enrolled 299 patients across eight European countries (mean age 68, 74% men). HF was defined using the European Society of Cardiology criteria, but only patients with a history of ejection fraction 
40% on echocardiography were recruited. WRF was defined as an increase in serum creatinine >26 µmol/L (
0.3 mg/dL) from admission. Follow-up was 95% complete to 6 months. Nearly one-third of patients [72 of 248 patients, 29% (95% CI 26–32%)] developed WRF during hospitalization, excluding patients who had a major in-hospital complication likely to compromise renal function. The risk of WRF in this group was independently associated with serum creatinine levels on admission [odds ratio (OR) 3.02 (95% CI 1.58–5.76)], pulmonary oedema [OR 3.35 (1.79–6.27)], and a history of atrial fibrillation [OR 0.35 (0.18–0.67)]. Although the mortality of WRF patients was not increased significantly, the length of stay was 2 days longer [median 11 days (90% range (4–41) vs. 9 days (4–34), P=0.006]. The re-hospitalization rate was similar in both groups.
Conclusion WRF is common in patients admitted to European hospitals with decompensated HF. Such patients have longer duration admissions, but a similar mortality and re-hospitalization rate to those without WRF (if patients experiencing a major in-hospital complication are excluded).
Key Words: Heart failure • Worsening renal function • Risk factors • Prognosis • Hospitalization
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