European Heart Journal Advance Access originally published online on March 21, 2006
European Heart Journal 2006 27(13):1597-1604; doi:10.1093/eurheartj/ehi833
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The association of oestrogen receptor 
-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study
1 Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol, BS8 2PR, UK
2 Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
3 Human Genetics Division, School of Medicine, University of Southampton School of Medicine, UK
Received 18 October 2005; revised 12 February 2006; accepted 23 February 2006; online publish-ahead-of-print 21 March 2006.
* Corresponding author. Tel: +44 117 928 7267; fax: +44 117 928 7325. E-mail address: d.a.lawlor{at}bristol.ac.uk
See page 1519 for the editorial comment on this article (doi:10.1093/eurheartj/ehl065)
Aims One previous study among women with established coronary heart disease found a gene–treatment interaction between the oestrogen receptor gene (ESR1) and hormone replacement in their association with high density lipoprotein cholesterol (HDL-c). We aimed to replicate these findings in a general population sample.
Methods and results Cross-sectional associations were assessed in a study of 3404 women from 23 towns across Britain who were aged 60–79 at the time of assessment and were described as white by the examining nurse. Women with the T-A haplotype [constructed from two single nucleotide polymorphisms (SNPs) in the first intron of ESR1: c454-397T>C (rs2234693) and c454-351A>G (rs9340799)], which was predicted to be associated with reduced oestrogen response, were more likely to have been past [per haplotype odds ratio 1.16 (95% CI 1.01, 1.33), P = 0.02] or to be current users [per haplotype odds ratio 1.19 (95% CI 0.99, 1.42), P = 0.05] of hormone replacement. However, there was no association between haplotype or either SNP and HDL-c or other cardiovascular disease risk factors and no statistical evidence of an interaction between hormone replacement use and haplotype or either SNP with respect to HDL-c or any other cardiovascular disease risk factors.
Conclusion Women with the T-A haplotype are more likely to use hormone replacement. However, genotyping of ESR1 rs2234693 or rs9340799 in post-menopausal women to tailor hormone replacement is unlikely to markedly improve cardiovascular risk.
Key Words: ESR1 • Oestrogen receptor • Hormone replacement • High density lipoprotein cholesterol
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in EHJ:
- Oestrogen receptor genetics: a needle that cuts through many haystacks?
- Amanda M. Shearman
EHJ 2006 27: 1519-1520.[Extract] [Full Text]
This article has been cited by other articles:
|
|
 |
|
  K. L. E. Klos, E. Boerwinkle, R. E. Ferrell, S. T. Turner, and A. C. Morrison ESR1 polymorphism is associated with plasma lipid and apolipoprotein levels in Caucasians of the Rochester Family Heart Study J. Lipid Res., August 1, 2008; 49(8): 1701 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kivimaki, G. Davey Smith, N. J. Timpson, D. A. Lawlor, G. D. Batty, M. Kahonen, M. Juonala, T. Ronnemaa, J. S. A. Viikari, T. Lehtimaki, et al. Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study Eur. Heart J., June 10, 2008; (2008) ehn252v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Pepine, W. W. Nichols, and D. F. Pauly Estrogen and Different Aspects of Vascular Disease in Women and Men Circ. Res., September 1, 2006; 99(5): 459 - 461. [Full Text] [PDF]
|
|
|
|
|
|
A. M. Shearman Oestrogen receptor genetics: a needle that cuts through many haystacks? Eur. Heart J., July 1, 2006; 27(13): 1519 - 1520. [Full Text] [PDF]
|
|