European Heart Journal Advance Access originally published online on June 13, 2006
European Heart Journal 2006 27(14):1685-1689; doi:10.1093/eurheartj/ehl058
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Increased expression of interleukin-10 in unstable plaque obtained by directional coronary atherectomy
1 First Department of Internal Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
2 Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
3 Miyazaki Medical Association Hospital, Miyazaki, Japan
Received 13 January 2006; revised 27 April 2006; accepted 12 May 2006; online publish-ahead-of-print 13 June 2006.
* Corresponding author. Tel: +81 985 85 0872; fax: +81 985 85 6596. E-mail address: imatak{at}med.miyazaki-u.ac.jp
Aims The present study investigates the expression and localization of interleukin (IL)-10, an important anti-inflammatory cytokine, in atherectomy specimens from patients with stable and unstable angina.
Methods and results Twenty-two patients with stable angina and 21 with unstable angina who underwent directional coronary atherectomy for de novo lesions were studied. The atherectomy specimens were morphologically assessed and immunohistochemically stained with antibodies for IL-10, macrophages, smooth muscle cells, and endothelial cells. The localization and immunopositive areas were evaluated using an image analysing system. Immunoreactivity for IL-10 was detected in coronary plaques, especially in macrophages. Immunopositive areas of macrophages and IL-10, as well as the incidence of thrombus formation, were significantly greater in specimens from patients with unstable angina than in those from patients with stable angina (macrophages, P<0.001; IL-10, P<0.05; thrombus formation, P<0.05; respectively). Even after adjustment, IL-10 expression and the incidence of thrombus formation were significantly greater in the unstable angina group (P<0.05, each). The immunoreactivities for smooth muscle cells and endothelial cells did not differ between the two groups.
Conclusion IL-10 was more frequently expressed in specimens from patients with unstable angina. This finding might contribute to a better understanding of plaque instability.
Key Words: Atherectomy • Atherothrombosis • Immunohistochemistry • Interleukin-10 • Unstable angina
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