European Heart Journal Advance Access originally published online on August 22, 2006
European Heart Journal 2006 27(18):2184-2188; doi:10.1093/eurheartj/ehl202
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Circulating endothelial progenitor cells correlate with erectile function in patients with coronary heart disease
1 Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany
2 Medizinische Klinik II, Innere Medizin (Kardiologie, Pneumologie), Universitätsklinikum Bonn, Germany
Received 2 January 2006; revised 27 July 2006; accepted 4 August 2006; online publish-ahead-of-print 22 August 2006.
* Corresponding author. Tel: +49 6841 1623289; fax: +49 6841 1623446. E-mail address: magnus{at}baumhaekel.de
Aims The aim of the study was to determine the influence of endothelial progenitor cells (EPC) on erectile dysfunction (ED). EPC play a major role in repair mechanisms of the endothelial monolayer, but the role of EPC in ED is unclear.
Methods and results Circulating levels of CD34+/KDR+ and CD133+ EPC were determined in 119 patients with known coronary artery disease. ED was evaluated with an ED-score generated from the KEED questionnaire. Prevalence of ED was 59.7%. In univariate analysis, age, hypertension, reduced left ventricular ejection fraction (LVEF), diabetes, and circulating levels of CD133+ EPC, but not cardiovascular drug treatment were associated with ED. Body mass index (BMI) was positively (r = 0.319, P=0.003) and high-density lipoprotein was negatively (r=–0.246, P=0.034) correlated with ED. Adjustment for age, diabetes, hypertension, BMI, smoking, LVEF, use of statins and lower urinary tract symptoms, and prior coronary intervention revealed low levels of circulating immature CD133+ EPC as independent risk factor for ED (95% CI –11.183 to –1.7371, P=0.008).
Conclusion Reduced levels of circulating CD133+ EPC are an independent risk factor for ED. Thus, EPC may be a link between cardiovascular risk factors, endothelial dysfunction, and ED.
Key Words: Erectile dysfunction • Endothelial progenitor cell • EPC • Heart disease
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