European Heart Journal Advance Access originally published online on July 3, 2006
European Heart Journal 2006 27(20):2394-2399; doi:10.1093/eurheartj/ehl120
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The effect of correcting for troponins on trends in coronary heart disease events in Finland during 1993–2002: the FINAMI study
1 KTL-National Public Health Institute, Mannerheimintie 166, FI-00300 Helsinki, Finland
2 North Karelia Central Hospital, Joensuu, Finland
3 Kuopio University Hospital, Kuopio, Finland
4 Turku University Hospital, Turku, Finland
5 Turku City Hospital, Turku, Finland
6 Oulu University Hospital and Biocenter Oulu, Oulu, Finland
Received 28 February 2006; revised 1 June 2006; accepted 8 June 2006; online publish-ahead-of-print 3 July 2006.
* Corresponding author. Tel: +358 9 4744 8620; fax: +358 9 4744 8338. E-mail address: veikko.salomaa{at}ktl.fi
See page 2373 for the editorial comment on this article (doi:10.1093/eurheartj/ehl226)
Aims The object of this study is to analyse the trends in coronary events in Finland during 1993–2002, correcting for the effect of troponins.
Methods and results A population-based myocardial infarction register recorded all coronary events (n=14 782) in four geographical areas of Finland during 1993–2002. Correction coefficients for the effect of troponins were calculated on the basis of 4359 coronary events, with simultaneous determination of troponins and the ‘old’ enzymatic markers of myocardial injury. Coronary mortality declined steeply, except in women aged 
75 years. The incidence of first coronary events declined 2.0% (95% confidence interval –3.0, –0.9%) per year among men and 1.0% (–2.7, 0.6%) per year among women aged 35–74 years. After correcting for the effect of troponins, also the decline among women became statistically significant: 2.7% (–4.5, –0.8%) per year. The effect of troponins tended to be stronger in women and older individuals than in men and younger individuals. The 28-day case fatality declined among men, but not among women. The effect of troponins on case fatality trends was weak.
Conclusion Declining trends in the incidence of coronary events in Finland during 1993–2002 were partly hidden by the effect of troponins. Both incidence and case fatality declines have contributed to the decline in mortality.
Key Words: Coronary heart disease • Troponins • Epidemiology
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in EHJ:
- Redefinition of myocardial infarction: new challenges and opportunities
- Véronique L. Roger
EHJ 2006 27: 2373-2375.[Extract] [Full Text]
This article has been cited by other articles:
|
|
 |
|
  H. D White Evolution of the definition of myocardial infarction: what are the implications of a new universal definition? Heart, June 1, 2008; 94(6): 679 - 684. [Full Text] [PDF]
|
|
|
|
 |
|
 V. L. Roger Redefinition of myocardial infarction: new challenges and opportunities Eur. Heart J., October 2, 2006; 27(20): 2373 - 2375. [Full Text] [PDF]
|
|