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European Heart Journal Advance Access originally published online on September 25, 2006
European Heart Journal 2006 27(20):2433-2439; doi:10.1093/eurheartj/ehl274
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Right ventricular involvement in Takotsubo cardiomyopathy

Dariusch Haghi1, Anastasios Athanasiadis2, Theano Papavassiliu1,*, Tim Suselbeck1, Stephan Fluechter1, Heiko Mahrholdt2, Martin Borggrefe1 and Udo Sechtem2

1 Medical Department, University Hospital Mannheim, Theodor-Kutzer-Ufer 1–3, Mannheim 68167, Germany
2 Division of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany

Received 15 June 2006; revised 3 August 2006; accepted 11 September 2006; online publish-ahead-of-print 25 September 2006.

* Corresponding author. Tel: +49 621 3832612; fax: +49 621 3832172. E-mail address: theano.papavassilliu{at}med.ma.uni-heidelberg.de

Aims The aim of our study is to assess the incidence and clinical significance of right ventricular (RV) involvement in Takotsubo cardiomyopathy (TTC).

Methods and results Between February 2002 and December 2005, 47 patients with TTC underwent cardiovascular magnetic resonance (CMR) at our institutions. 13 patients with delayed initial CMR were excluded. In the remaining 34 patients (32 women), RV wall motion abnormalities (WMAs) were present in nine (26%). Left ventricular ejection fraction (LVEF) was significantly lower in patients with RV involvement (40±6 vs. 48±10%, P=0.04). The most frequently affected RV segments were the apico-lateral (89%), the antero-lateral (67%), and the inferior segment (67%). All RV WMA improved or disappeared in eight of nine patients who underwent a follow-up CMR study. Pleural effusion was more common in patients with RV involvement (67 vs. 8%, P<0.001) and was predictive of RV dysfunction (sensitivity 67% and specificity 92%). Significant or bilateral pleural effusions were seen exclusively in patients with RV involvement.

Conclusion RV involvement is common in TTC and seems to be associated with a more severe impairment in LV systolic function. It may be suspected by the presence of pleural effusion.

Key Words: Takotsubo cardiomyopathy • Apical ballooning syndrome • Right ventricle


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