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European Heart Journal Advance Access originally published online on September 5, 2006
European Heart Journal 2006 27(21):2524-2529; doi:10.1093/eurheartj/ehl231
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population

Werner Koch1,*, Petra Hoppmann1, Arne Pfeufer2, Albert Schömig1 and Adnan Kastrati1

1 Deutsches Herzzentrum München, Lazarettstrasse 36, 80636 München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
2 Institut für Humangenetik, Klinikum rechts der Isar, Technische Universität München, Munich, and Institut für Humangenetik, GSF Forschungszentrum, Neuherberg, Germany

Received 3 March 2006; revised 29 June 2006; accepted 17 August 2006; online publish-ahead-of-print 5 September 2006.

* Corresponding author. Tel: +49 89 1218 2601; fax: +49 89 1218 3053. E-mail address: wkoch{at}dhm.mhn.de

See page 2489 for the editorial comment on this article (doi:10.1093/eurheartj/ehl299)

Aims The toll-like receptor 4 (TLR4) is predominantly known for its role as an important mediator of immune reactions and has been implicated in the initiation, progression, and plaque destabilization stages of atherosclerosis. We investigated whether genotypes and haplotypes of the 896A/G (Asp299Gly; rs4986790) and 1196C/T (Thr399Ile; rs4986791) single nucleotide polymorphisms of the gene encoding the TLR4 were associated with myocardial infarction (MI) in a large Caucasian sample.

Methods and results The case group included 3657 patients with MI and the control group comprised 1211 individuals with angiographically normal coronary arteries and without signs or symptoms of MI. Genotypes were determined with the use of TaqMan assays. Genotype distributions of the 896A/G and 1196C/T polymorphisms were not significantly different between the control and patient groups (P≥0.30). The frequencies of haplotypes defined by the 896A/G and 1196C/T polymorphisms were similar between the control group and the patient group (P≥0.16). In addition, the distributions of haplotype-defined genotypes (diplotypes) were not significantly different between the control group and the patient group (P≥0.12). Separate analyses in women and men did not reveal sex-related associations of specific genotypes or haplotypes of the polymorphisms with MI (P≥0.11).

Conclusion The results indicate that the 896A/G and 1196C/T polymorphisms of the TLR4 gene or haplotypes based on these polymorphisms are not associated with MI.

Key Words: Atherosclerosis • Myocardial infarction • TLR4 • Toll-like receptor 4 • Genetics • Haplotype


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