European Heart Journal Advance Access originally published online on October 4, 2006
European Heart Journal 2006 27(23):2784-2814; doi:10.1093/eurheartj/ehl282
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Mortality in randomized controlled trials comparing drug-eluting vs. bare metal stents in coronary artery disease: a meta-analysis
Basel Institute for Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, 4031 Basel, Switzerland
Received 28 April 2006; revised 20 July 2006; accepted 11 September 2006; online publish-ahead-of-print 4 October 2006.
* Corresponding author. Tel: +41 61 265 31 00; fax: +41 61 265 31 09. E-mail address: nordmanna{at}uhbs.ch
See page 2737 for the editorial comment on this article (doi:10.1093/eurheartj/ehl378)
Aims To evaluate the effect of drug-eluting vs. bare metal stents for the treatment of coronary artery disease on overall, cardiac, and non-cardiac mortalities.
Methods and results We conducted a systematic literature search to identify all randomized controlled trials comparing sirolimus or paclitaxel-eluting stents with bare metal stents and reporting mortality data after at least 1 year of follow-up. Trial data were reviewed and extracted independently by two investigators in an unblinded standardized manner. Seventeen trials including a total of 8221 patients were analysed. Peto's odds ratios (ORs) for total mortality after 1 (n=8221), 2 (n=4631), 3 (n=4105), and 4 (n=1293) years of follow-up were 0.94 [95% confidence interval (CI) 0.66–1.34], 1.11 (95% CI 0.76–1.61), 1.25 (95% CI 0.91–1.73), and 1.46 (95% CI 0.92–2.31), respectively. Corresponding ORs for non-cardiac mortality were 1.07 (95% CI 0.64–1.80), 1.72 (95% CI 1.01–2.94), 1.45 (95% CI 0.93–2.25), and 1.65 (95% CI 0.89–3.10). There was no difference in OR for cardiac mortality among all trials. In sensitivity analyses, sirolimus- but not paclitaxel-eluting stents were associated with an increase in non-cardiac mortality at 2 and 3 years of follow-up.
Conclusion Drug-eluting stents for the treatment of coronary artery disease do not reduce total mortality when compared with bare metal stents. Preliminary evidence suggests that sirolimus- but not paclitaxel-eluting stents may lead to increased non-cardiac mortality. Long-term follow-up and assessment of cause-specific deaths in patients receiving drug-eluting stents is mandatory to determine the long-term safety of these devices.
Key Words: Drug-eluting stents • Meta-analysis • Coronary artery disease
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