European Heart Journal Advance Access originally published online on November 29, 2006
European Heart Journal 2006 27(24):3057-3064; doi:10.1093/eurheartj/ehl401
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Reduction in infarct size, but no functional improvement after bone marrow cell administration in a porcine model of reperfused myocardial infarction
1 Department of Cardiology, Thoraxcenter, Ba 587, Erasmus MC, University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
2 Department of Radiology, Erasmus MC Rotterdam, The Netherlands
3 Interuniversity Cardiology Institute of The Netherlands, The Netherlands
Received 1 August 2006; revised 19 October 2006; accepted 7 November 2006; online publish-ahead-of-print 29 November 2006.
* Corresponding author. Tel: +31 10 4635245; fax: +31 10 4634320. E-mail address: w.j.vandergiessen{at}erasmusmc.nl
Aims Stem cell therapy after myocardial infarction (MI) has been studied in models of permanent coronary occlusion. We studied the effect of intracoronary administration of unselected bone marrow (BM) and mononuclear cells (MNC) in a porcine model of reperfused MI.
Methods and results In 34 swine, the left circumflex coronary artery was balloon-occluded for 2 h followed by reperfusion. Ten swine without MI served as controls. All swine underwent magnetic resonance imaging (MRI) 1 week post-MI. The next day, 10 of the 30 surviving MI swine received BM, 10 other MI swine received MNC, and the remaining MI swine received medium intracoronary. Four weeks later, all swine underwent a follow-up MRI. One week after MI, end-diastolic volume (92±16 mL) and left ventricular (LV) weight (78±12 g) were greater, whereas ejection fraction (40±8%) was lower than in controls (69±11 mL, 62±13 g, and 53±6%). Injection of BM or MNC had no effect on the MI-induced changes in global or regional LV-function. However, there was a significant reduction in infarct size 4 weeks after MNC injection (–6±3%) compared with the medium (–3±5%).
Conclusion Intracoronary injection of BM or MNC in swine does not improve regional or global LV-function 4 weeks after injection. However, a reduction in infarct-size was noted after MNC injection.
Key Words: Myocardial infarction • Bone marrow stem cells • Left ventricular function • Magnetic resonance imaging • Infarct size • Swine
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