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European Heart Journal Advance Access originally published online on November 2, 2005
European Heart Journal 2006 27(3):283-289; doi:10.1093/eurheartj/ehi628
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction

Wojciech Wojakowski1,*, Michal Tendera1, Anna Zebzda2, Anna Michalowska2, Marcin Majka2, Magdalena Kucia3, Katarzyna Maslankiewicz1, Rafal Wyderka1, Marek Król1, Andrzej Ochala1, Krystyna Kozakiewicz1 and Mariusz Z. Ratajczak2,3

13rd Division of Cardiology, Silesian School of Medicine, 45-47 Ziolowa Street, 40-635 Katowice, Poland
2Department of Transplantology, Polish-American Children's Hospital, Medical College, Jagiellonian University, 265 Wielicka Street, 30-663 Kraków, Poland
3Stem Cell Biology Program at James Graham Brown Cancer Center and Department of Medicine, University of Louisville, Louisville, KY 40202, USA

Received 28 February 2005; revised 6 October 2005; accepted 13 October 2005; online publish-ahead-of-print 2 November 2005.

* Corresponding author. Tel: +48 50 419 7669; fax: +48 32 252 3930. E-mail address: wojwoj{at}mp.pl

Aims The aim of the study was to assess the correlation between the number of CD34+, CD117+, c-met+, CXCR4+ stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI).

Methods and results 43 patients with STEMI were enrolled. Stem cells number was measured using flow-cytometer and concentrations of NT-proBNP, SDF-1, G-CSF, VEGF, IL-6, and HGF were measured using ELISA kits. The number of stem cells mobilized early (<12 h) in AMI was significantly, positively correlated with LVEF: r=0.49 (P=0.0012) for CD34+ cells, r=0.48 (P=0.0018) for CXCR4+ cells, r=0.45 (P=0.0043) for CD117+ cells, and r=0.41 (P=0.01) for c-met+ cells and negatively correlated with NT-proBNP levels on admission r=–0.35 (P=0.024) for CD34+ cells, r=–0.42 (P=0.007) for CXCR4+ cells, r=–0.33 (P=0.04). In patients with LVEF ≤40%, the peak number of CD34+, CXCR4+, CD117+, and c-met+ stem cells was significantly lower when compared patients with LVEF >40%. The number of CXCR4+ cells on admission and after 24 h was negatively correlated with respective cardiac Troponin I levels (r=–0.37; P=0.029 and r=–0.45, P=0.02) and maximum activity of CK-MB (r=–0.37; P=0.021). No significant correlations between levels of haematopoietic cytokines and LVEF were found.

Conclusion The mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.

Key Words: Blood cells • Myocardial infarction • Inflammation • Left ventricular ejection fraction • Natriuretic peptides


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