European Heart Journal Advance Access originally published online on January 18, 2006
European Heart Journal 2006 27(7):808-816; doi:10.1093/eurheartj/ehi737
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The CAREGENE study: polymorphisms of the ß1-adrenoceptor gene and aerobic power in coronary artery disease
ska3
1Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, Tervuursevest 101, 3000 Leuven, Belgium
2Department of Human Genetics, Centre for Human Genetics, University Hospitals Leuven, Leuven, Belgium
3Department of Rehabilitation, Medical University of Gdansk, Gdansk, Poland
4Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, K.U. Leuven, Leuven, Belgium
Received 16 September 2005; revised 11 December 2005; accepted 23 December 2005; online publish-ahead-of-print 18 January 2006.
* Corresponding author. Tel: +32 16 329005; fax: +32 16 329197. E-mail address: luc.vanhees{at}faber.kuleuven.be
This paper was guest edited by Prof. Eloisa Arbustini, IRCCS Policlinico S. Matteo, Italy
Aims The heritability of aerobic power and of the response to physical training has been shown in healthy subjects. ß1-Adrenergic receptor (ß1AR) function affects exercise performance. This study aims to investigate whether the Ser49Gly and Gly389Arg polymorphisms of the ß1AR gene or their haplotypes are associated with aerobic power or its response to physical training in coronary artery disease (CAD).
Methods and results Nine hundred and thirty-five biologically unrelated Caucasian patients with CAD who had exercised until exhaustion during graded bicycle testing at baseline and after completion of 3 months of exercise training from 1990 to 2001 (n=1095) were eligible for inclusion in the CAREGENE (CArdiac REhabilitation and GENetics of Exercise performance) study. Polymorphisms were detected using the invader assay (Third Wave TechnologiesTM, Madison, Wisconsin, USA). Patients with the Gly49Gly genotype had significantly higher covariate-adjusted aerobic power at baseline than those with Ser49Ser and Ser49Gly (P<0.05). Adjusted aerobic power at baseline was highest in the Ser49–Gly389/Gly49–Gly389 and Gly49–Arg389/Gly49–Arg389 haplotype combinations. Aerobic power increased significantly (P<0.001) with physical training. There was no association with the effect of physical training.
Conclusion Ser49Gly and haplotype combinations of Ser49Gly and Gly389Arg of the ß1AR gene are associated with aerobic power, but not with the response to physical training in patients with CAD included in the CAREGENE study.
Key Words: ß-Adrenergic receptor • Cardiac rehabilitation • Exercise • Genetics • Oxygen uptake • Polymorphism
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