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European Heart Journal Advance Access originally published online on February 2, 2006
European Heart Journal 2006 27(9):1032-1037; doi:10.1093/eurheartj/ehi761
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarction

Kathrin Schömig, Gabriele Busch, Birgit Steppich, Dominik Sepp, Jan Kaufmann, Andreas Stein, Albert Schömig and Ilka Ott*

Deutsches Herzzentrum und 1. Medizinische Klinik der Technischen Universität München, Lazarettstr. 36, 80636 München, Germany

Received 18 August 2005; revised 13 December 2005; accepted 13 January 2006; online publish-ahead-of-print 2 February 2006.

* Corresponding author. Tel: +49 89 1218 3515; fax: +49 89 1218 4013. E-mail address: ott{at}dhm.mhn.de

See page 1013 for the editorial comment on this article (doi:10.1093/eurheartj/ehi889)

Aims Release of progenitor cells is observed during inflammatory conditions and contributes to neovascularization. We, therefore, sought to investigate the relationship of circulating progenitor cells and interleukin (IL)-8 in acute myocardial infarction (AMI).

Methods and results From patients with stable angina and AMI, serial venous blood samples were obtained. The number of circulating CD133+CD45– progenitor cells, endothelial progenitor cells (EPCs), and circulating endothelial P1H12+CD45– cells was analyzed by flow cytometry. After stenting in patients with AMI, an increase in plasma IL-8 and vascular endothelial growth factor (VEGF) concentrations was observed, which was only minimal in patients with stable angina. Only in patients with AMI, this was followed by an increase in circulating CD133+CD45– progenitor cells. In contrast, circulating endothelial P1H12+CD45– cells and E-selectin RNA expression in peripheral blood were only elevated early in AMI, indicating shedding of activated endothelial cells. Multivariable analysis revealed an association of IL-8 and circulating CD133+CD45– progenitor cells in AMI, in addition to statin therapy and risk factor profile.

Conclusion In AMI, IL-8 is associated with circulating progenitor cells. In addition to the pro-angiogenic functions of IL-8 and VEGF, this mechanism may contribute to new vessel generation and, thereby, improve myocardial function.

Key Words: Myocardial infarction • Cytokines


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