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European Heart Journal Advance Access originally published online on October 10, 2006
European Heart Journal 2007 28(1):65-71; doi:10.1093/eurheartj/ehl315
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Clinical and prognostic profile of patients with infective endocarditis who need urgent surgery

Ana Revilla1,*, Javier López1, Isidre Vilacosta2, Eduardo Villacorta1, María J. Rollán3, José R. Echevarría1, Yolanda Carrascal1, Salvatore Di Stefano1, Enrique Fulquet1, Enrique Rodríguez2, Luis Fiz1 and José A. San Román1

1 Department of Cardiology and Cardiac Surgery, Institute of Heart Sciences (ICICOR), Hospital Clínico Universitario, Ramón y Cajal 3-5, 47005 Valladolid, Spain
2 Department of Cardiology and Cardiac Surgery, Hospital Clínico San Carlos, Madrid, Spain
3 Department of Cardiology, Hospital Río Hortega, Valladolid, Spain

Received 26 May 2006; revised 20 September 2006; accepted 28 September 2006; online publish-ahead-of-print 10 October 2006.

* Corresponding author. Tel: +34 983420026; fax: +34 983255305. E-mail address: arevillaorodea{at}gmail.com

Aims Surgery in patients with infective endocarditis (IE) can be elective (upon completion of antibiotic treatment) or urgent (before antibiotic treatment has ended) when the clinical course is unfavourable. However, urgent surgery for left-sided endocarditis is associated with high mortality. The aims of this study were to describe the profile of patients with left-sided endocarditis who underwent urgent surgery and to analyse the factors that predicted mortality.

Methods and results Among 508 consecutive episodes of IE, 391 were left-sided and 89 required urgent surgery. The main reasons for urgent surgery were heart failure that did not respond to medication (72%) and persistent infection despite appropriate antibiotic treatment (31%). Thirty-two patients (36%) died during their hospital stay. Univariate analysis identified renal failure, septic shock, Gram-negative bacteria, persistent infection, and surgery for persistent infection as factors associated with mortality. Multivariate analysis confirmed only persistent infection and renal insufficiency as factors independently associated with a poor prognosis.

Conclusion Patients with IE who need urgent surgery have a poor clinical course. Heart failure, the main cause of urgent surgery, was not associated with higher mortality. However, persistent infection and renal failure were factors associated with higher post-surgical mortality.

Key Words: Endocarditis • Cardiac surgical procedures • Prognosis • Renal insufficiency • Congestive heart failure • Hospital mortality


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