European Heart Journal Advance Access originally published online on July 18, 2007
European Heart Journal 2007 28(17):2142-2147; doi:10.1093/eurheartj/ehm272
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Contribution of changes in incidence and mortality to trends in the prevalence of coronary heart disease in the UK: 1996–2005
1 Department of Epidemiology and Population Health, Centre for Population Studies, London School of Hygiene and Tropical Medicine, 49–51 Bedford Square, London WC1B 3DP, UK
2 Department of Epidemiology and Population Health, Non-communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Received 23 February 2007; revised 30 May 2007; accepted 7 June 2007; online publish-ahead-of-print 18 July 2007.
* Corresponding author. Tel: +44 20 7299 4762; fax: +44 20 7299 4637. E-mail address: alisha.davies{at}lshtm.ac.uk
See page 2051 for the editorial comment on this article (doi:10.1093/eurheartj/ehm323)
Aims: To assess how trends in the incidence of coronary heart disease (CHD) and mortality rates among people with CHD have affected the prevalence of CHD in the UK.
Methods and results: A time trend analysis using computerized general practice clinical records of people aged 35 years and over was performed. From 1996 to 2005, age-standardized incidence of CHD decreased by 2.2% in men and 2.3% in women per year (average percentage change). Age-standardized all-cause mortality among those with CHD decreased by 4.5% in men and 3.4% in women per year (average percentage change). Age-standardized prevalence increased by 1.3% in men and 1.7% in women per year (average percentage change). Although the decline in incidence had some impact on limiting the increase in prevalence, its effect was offset by the increase in prevalence occurring as a result of improved survival among people with CHD.
Conclusion: The results suggest that increasing prevalence is largely due to decreasing mortality among people with CHD. Further increases in prevalence are likely even if the incidence of CHD continues to fall.
Key Words: Coronary heart disease • Prevalence • Incidence • Mortality • United Kingdom • Trends
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