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European Heart Journal Advance Access originally published online on September 13, 2007
European Heart Journal 2007 28(21):2568-2577; doi:10.1093/eurheartj/ehm341
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Management of atrial fibrillation in patients with heart failure

Hans-Ruprecht Neuberger1,*, Christian Mewis1, Dirk J. van Veldhuisen2, Ulrich Schotten3, Isabelle C. van Gelder2, Maurits A. Allessie3 and Michael Böhm1

1 Klinik für Innere Medizin III, Kardiologie, Angiologie, und Internistische Intensivmedizin;, Universitätsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany
2 Department of Cardiology, University Medical Center Groningen, The Netherlands
3 Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands

Received 2 March 2007; revised 6 July 2007; accepted 17 July 2007; online publish-ahead-of-print 13 September 2007.

* Corresponding author. Tel: +49 6841 162 3000; fax: +49 6841 162 3381. E-mail address: h.neuberger{at}tiscali.de

Atrial fibrillation (AF) and chronic heart failure (CHF) are two major and even growing cardiovascular conditions that often coexist. However, few data are available to guide treatment of AF in patients with CHF. This review summarizes current literature concerning the following topics: (i) prognostic relevance of AF in patients with CHF, (ii) relevance and strategies of rhythm and rate control in patients with AF and CHF, and (iii) options for prevention of AF in patients with ventricular dysfunction. In conclusion, AF is associated with increased mortality in CHF patients. However, it is not clear whether there is a causal relationship. Emerging strategies to prevent the occurrence of AF are promising tools that might improve quality of life and survival in patients with CHF.

Key Words: Atrial fibrillation • Heart failure • Clinical trials


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