European Heart Journal Advance Access originally published online on October 17, 2007
European Heart Journal 2007 28(22):2770-2777; doi:10.1093/eurheartj/ehm390
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study
1 Department of Cardiology, Québec Heart Institute, Hôpital Laval Research Centre, Pavilion Marguerite-D'Youville, 4th Floor, 2725, chemin Sainte-Foy, Québec, QC, Canada G1V 4G5
2 Department of Anatomy and Physiology, Faculty of Medicine, Université Laval, Québec, QC, Canada
3 Division of Kinesiology, Department of Social and Preventive Medicine, Université Laval, Québec, QC, Canada
4 Medical Research Council Epidemiology Unit, Cambridge, UK
5 Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
6 Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
7 Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands
Received 10 January 2007; revised 21 June 2007; accepted 23 August 2007; online publish-ahead-of-print 17 October 2007.
* Corresponding author. Tel: +1 418 656 4863; fax: +1 418 656 4610. E-mail address: jean-pierre.despres{at}crhl.ulaval.ca
Aims: To evaluate the association of low-density lipoprotein cholesterol (LDL-C) levels in small and large LDL particles with risk of incident coronary heart disease (CHD).
Methods and results: We performed a prospective case-control study nested in the EPIC-Norfolk cohort. Cases were apparently healthy men and women aged 45–79 years who developed fatal or non-fatal CHD (n = 1035), and who were matched by age, gender, and enrollment time to 1920 controls who remained free of CHD. Electrophoretic characteristics of LDL particles were measured using 2–16% polyacrylamide gradient gel electrophoresis. Concentrations of LDL-C<255 Å were higher in cases than controls in men (1.34 ± 0.88 vs. 1.15 ± 0.80 mmol/L, P < 0.001) as well as in women (1.12 ± 0.84 vs. 0.94 ± 0.74 mmol/L, P < 0.001). The unadjusted odds ratio (OR) for future CHD in men of the top tertile of LDL-C<255 Å was 1.68 (95% CI, 1.33–2.13; P < 0.001) whereas in women the unadjusted OR was 1.53 (95% CI, 1.13–2.07; P < 0.001). However, after further adjustments for confounding variables, the association between LDL-C<255 Å and CHD was no longer significant in men and in women.
Conclusion: Cholesterol concentrations in different LDL subclasses show different relationships with CHD risk in this European cohort.
Key Words: Epidemiology • Gender • Lipids • Risk factors • LDL particle size
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Ip, A. H. Lichtenstein, M. Chung, J. Lau, and E. M. Balk Systematic Review: Association of Low-Density Lipoprotein Subfractions With Cardiovascular Outcomes Ann Intern Med, April 7, 2009; 150(7): 474 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mathieu, P. Poirier, P. Pibarot, I. Lemieux, and J.-P. Despres Visceral Obesity: The Link Among Inflammation, Hypertension, and Cardiovascular Disease Hypertension, April 1, 2009; 53(4): 577 - 584. [Full Text] [PDF]
|
|