European Heart Journal Advance Access originally published online on October 29, 2007
European Heart Journal 2007 28(24):2992-2997; doi:10.1093/eurheartj/ehm483
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Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischaemia: results in vasospastic angina pectoris induced by provocation test
1 Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
2 Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan
3 Department of Cardiovascular Medicine, University of Fukui Hospital, Fukui, Japan
4 Department of Legal Medicine, Faculty of Medicine, Shimane University, Izumo, Japan
5 Department of Legal Medicine, Gunma University Graduate School of Medicine, Gunma, Japan
6 Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui 910-1193, Japan
Received 22 March 2007; revised 12 September 2007; accepted 26 September 2007; online publish-ahead-of-print 29 October 2007.
* Corresponding author. Tel: +81 776 61 8287; fax: +81 776 61 8149.E-mail address: tyasuda{at}u-fukui.ac.jp
See page 2955 for the editorial comment on this article (doi:10.1093/eurheartj/ehm409)
Aims: Serum deoxyribonuclease I (DNase I) activity has recently been highlighted as a potential diagnostic marker for detection of acute myocardial infarction. To evaluate whether serum DNase I activity is useful for detection of myocardial ischaemia, we investigated alteration of its levels after onset of vasospastic angina pectoris (VSAP), resulting in transient myocardial ischaemia, induced by the intracoronary ergonovine provocation test.
Methods and results: Twenty-nine consecutive patients with suspected VSAP were subjected to the test. Patients were categorized as VSAP-positive (n = 13) or -negative (n = 16) based on development of angina. Serum samples were examined for DNase I activity before, immediately after, and 3, 6, and 24 h after the provocation tests. The serum DNase I activity increased significantly from the baseline 3 h after the provocation test in 11 patients of the VSAP-positive group whose levels of troponin T were within the normal range. Median of the percentage differences from the baseline in serum DNase I activity 3 h after the test was 32.1% (25th and 75th percentile: 28.6 and 42.0%, respectively; P = 0.000012). In the VSAP-negative group, levels of DNase I activity remained unchanged at any point of time after the provocation test.
Conclusion: Transient myocardial ischaemia resulting from VSAP induces a significant elevation of serum DNase I activity. Therefore, serum DNase I activity may be applicable as a useful marker for detecting transient myocardial ischaemia.
Key Words: Ischaemia • Vasospastic angina pectoris • Deoxyribonuclease I
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- Ability of DNase I activity to detect myocardial ischaemia in vasospastic angina—a view through a monocle?
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EHJ 2007 28: 2955-2956.[Extract] [Full Text]
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  E. Giannitsis and H. A. Katus Ability of DNase I activity to detect myocardial ischaemia in vasospastic angina a view through a monocle? Eur. Heart J., December 2, 2007; 28(24): 2955 - 2956. [Full Text] [PDF]
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