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European Heart Journal Advance Access originally published online on January 16, 2007
European Heart Journal 2007 28(3):305-309; doi:10.1093/eurheartj/ehl460
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: results from the KORA study

Mahmut Akyol1,2,{dagger}, Shapour Jalilzadeh1,2,{dagger}, Moritz F. Sinner1,3, Siegfried Perz4, Britt M. Beckmann3, Christian Gieger5, Thomas Illig5, H.-Erich Wichmann5, Thomas Meitinger1,2, Stefan Kääb3 and Arne Pfeufer1,2,*

1 Institute of Human Genetics (IHG), GSF National Research Centre of Environment and Health, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany
2 Institute of Human Genetics (IHG), Technical University of Munich, Klinikum rechts der Isar, Trogerstr. 32, D-81675 Munich, Germany
3 Department of Medicine I, Ludwigs-Maximilians University Munich, Klinikum Grosshadern, Marchioninistr 15, D-81377 Munich, Germany
4 Institute of Medical Informatics (IMEI), GSF National Research Centre of Environment and Health, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany
5 Institute of Epidemiology (EPI), GSF National Research Centre of Environment and Health, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany

Received 12 October 2006; revised 19 November 2006; accepted 14 December 2006; online publish-ahead-of-print 16 January 2007.

* Corresponding author. Tel: +49 89 3187 3545; fax: +49 89 3187 3474. E-mail address: arne.pfeufer{at}web.de

Aims The QT interval in the general population is a complex trait with 30–50% heritability. QT prolongation is associated with an increased risk of sudden death. A recent family-based study found an association between QT interval and the common non-synonymous Glycin 38 Serine variant (G38S, rs1805127) of the KCNE1 gene coding for the minK-potassium channel subunit. We intended to replicate this finding in a large population sample of central European Caucasian ancestry as part of our ongoing search for genetic variants predisposing to arrhythmias.

Methods and results We studied 3966 unrelated individuals from the KORA S4 population-based study without atrial fibrillation, pacemaker implant, or pregnancy. Individuals were genotyped by MALDI-TOF mass spectrometry. We did not detect any significant association between the genotypes of the G38S variant and the QT interval in the entire population or in any gender.

Conclusion Unlike the common Lysine 897 Threonine variant of KCNH2 (K897T, rs1805123) the G38S variant of KCNE1 does not appear to have a strong modifying effect on QT interval. However, we cannot rule out an effect of G38S on QT in other ethnic groups, under exercise or medications or on the risk for arrhythmias and sudden death.

Key Words: Cardiac repolarization • Genetic association study • Single nucleotide polymorphism (SNP) • Genetic epidemiology


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