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European Heart Journal Advance Access originally published online on January 22, 2007
European Heart Journal 2007 28(3):310-315; doi:10.1093/eurheartj/ehl458
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Sex-related aspects on abnormal glucose regulation in patients with coronary artery disease

Annika Dotevall1,*, Annika Rosengren1, Malgorzata Bartnik2, Klas Malmberg2, John Öhrvik2, Maarten Simoons3, Lars Rydén on behalf of the Euro Heart Survey Investigators2

1 Department of Medicine, Sahlgrenska University Hospital/Östra, S-416 85 Göteborg, Sweden
2 Department of Cardiology, Karolinska University Hospital, Solna, Stockholm, Sweden
3 Thoraxcenter, Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Received 15 July 2006; revised 9 November 2006; accepted 14 December 2006; online publish-ahead-of-print 22 January 2007.

* Corresponding author. Tel: +46 31 343 40 84; fax: +46 31 25 92 54. E-mail address: annika.dotevall{at}vgregion.se

Aim To investigate the prevalence of diabetes and impaired glucose regulation (IGR) in a large cohort of men and women with coronary artery disease (CAD), and to describe the effect of abnormal glucose regulation by sex on symptoms, clinical course, and diagnosis.

Methods and results A total of 4855 patients with CAD (median age 66 years; 29% women) were analysed within the framework of the Euro Heart Survey on Diabetes and the Heart. In all, 967 (28.1%) men and 528 (37.5%) women had diabetes. Of 3185 patients with unknown glucose regulation, 1835 (57.6%; 1400 men and 435 women) underwent an oral glucose tolerance test revealing that 17% of the men and 18% of the women had diabetes and 35 and 39% impaired glucose tolerance or impaired fasting glucose, respectively. Thus, only 19% of the women and 27% of the men had a normal glucose regulation. Women were more likely to have diabetes than men with an odds ratio (OR) of 1.32 (1.13–1.54). The corresponding OR for abnormal glucose regulation was 1.34 (1.11–1.62). Gender did not influence differences in clinical presentation between patients with diabetes or IGR and those with a normal glucose metabolism.

Conclusion Abnormal glucose regulation was more common in women than men with CAD. However, the influence of diabetes on presenting symptoms and clinical course was similar in men and women.

Key Words: Diabetes • Coronary artery disease • Euro Heart Survey on Diabetes and the Heart • Women • IGT


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