Skip Navigation


European Heart Journal Advance Access originally published online on November 23, 2006
European Heart Journal 2007 28(6):673-678; doi:10.1093/eurheartj/ehl404
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
28/6/673    most recent
ehl404v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tumminello, G.
Right arrow Articles by Piérard, L. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tumminello, G.
Right arrow Articles by Piérard, L. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Exercise ventilation inefficiency in heart failure: pathophysiological and clinical significance

Gabriele Tumminello1, Marco Guazzi1, Patrizio Lancellotti2 and Luc A. Piérard2,*

1 Cardiopulmonary Unit, Cardiology Division, University of Milano, San Paolo Hospital, 20142 Milano, Italy
2 Department of Cardiology, University Hospital Sart Tilman, Boite 35 CHU, B-4000 Liège, Belgium

Received 24 May 2006; revised 8 September 2006; accepted 7 November 2006; online publish-ahead-of-print 23 November 2006.

* Corresponding author. Tel: +32 4 366 71 94; fax: +32 4 366 71 95. E-mail address: lpierard{at}chu.ulg.ac.be

Heart failure (HF) is a complex syndrome characterized by myocardial dysfunction and a poor prognosis. Among multiple markers of severity, an exercise ventilation inefficiency has important clinical and prognostic value. The pathophysiology determining exercise ventilatory inefficiency is complex and not definitively clarified. Three different mechanisms have been identified: (i) increased dead space, (ii) early occurrence of lactic acidosis, and (iii) abnormal chemoreflex and/or metaboreflex activity. Besides its prognostic value, abnormal ventilation can be influenced by pharmacological and non-pharmacological therapies such as ß-blockers, selective cyclic 3'–5' guanosine monosphosphate phosphodiesterase inhibitors, physical training, and nocturnal continuous positive airway pressure. There is an increasing interest for the exercise periodic breathing, which is frequently associated with HF syndrome and has prognostic importance. The precise mechanisms sustaining exercise periodic breathing are not fully defined but ventilatory and metabo-haemodynamic hypotheses have been proposed.

Key Words: Heart failure • Ventilation • Exercise • Periodic breathing


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
T. Maros
Fractional flow reserve: a reliable tool in bypass strategy
Eur. J. Cardiothorac. Surg., March 1, 2009; 35(3): 556 - 556.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
L. Ingle
Prognostic value and diagnostic potential of cardiopulmonary exercise testing in patients with chronic heart failure
Eur J Heart Fail, February 1, 2008; 10(2): 112 - 118.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.