Skip Navigation


European Heart Journal Advance Access originally published online on March 8, 2007
European Heart Journal 2007 28(7):788-797; doi:10.1093/eurheartj/ehl501
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
28/7/788    most recent
ehl501v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lerman, A.
Right arrow Articles by Gersh, B. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lerman, A.
Right arrow Articles by Gersh, B. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Microcirculatory dysfunction in ST-elevation myocardial infarction: cause, consequence, or both?

Amir Lerman*, David R. Holmes, Joerg Herrmann and Bernard J. Gersh

Division of Cardiovascular Disease and Department of Internal Medicine, Mayo Clinic and College of Medicine, 200 First Street SW, Rochester, MN 55902, USA

Received 10 October 2006; revised 19 December 2006; accepted 4 January 2007; online publish-ahead-of-print 8 March 2007.

* Corresponding author. Tel: +1 507 255 4152; fax: +1 507 255 2550. E-mail address: lerman.amir{at}mayo.edu

Aims: Despite advancements over the past years, normal reperfusion at the myocardial level is not achieved in approximately every other patient with ST-elevation myocardial infarction. In the current work, we aimed at reviewing the role of the coronary microcirculation in the development and outcome of this acute coronary syndrome entity.

Methods and results: A PubMed/Medline search was performed with the key words acute coronary syndrome, acute myocardial infarction, coronary artery disease, endothelial dysfunction, microcirculation, and reperfusion. The synthesis of the information points to myocardial microcirculatory dysfunction as a consequence of a primary epicardial event, based on the vulnerable plaque concept. As an alternative theory, microcirculatory dysfunction may contribute to the clinical course of the acute coronary event, based on the vulnerable patient concept. The pros and cons of these two viewpoints are to be discussed and their influence on patient management is to be considered.

Conclusion: Microcirculatory dysfunction in ST-elevation myocardial infarction can be cause, consequence or both according to non-traditional and traditional concepts.

Key Words: Acute coronary syndrome • Myocardial infarction • Endothelium • Microcirculation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
R. Rubinshtein, E. H. Yang, C. S. Rihal, A. Prasad, R. J. Lennon, P. J. Best, L. O. Lerman, and A. Lerman
Coronary microcirculatory vasodilator function in relation to risk factors among patients without obstructive coronary disease and low to intermediate Framingham score
Eur. Heart J., November 5, 2009; (2009) ehp459v1.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Escaned, A. Flores, P. Garcia-Pavia, J. Segovia, J. Jimenez, P. Aragoncillo, C. Salas, F. Alfonso, R. Hernandez, D. J. Angiolillo, et al.
Assessment of Microcirculatory Remodeling With Intracoronary Flow Velocity and Pressure Measurements: Validation With Endomyocardial Sampling in Cardiac Allografts
Circulation, October 20, 2009; 120(16): 1561 - 1568.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
G. Barletta, S. Del Pace, M. Boddi, R. Del Bene, C. Salvadori, B. Bellandi, M. Coppo, E. Saletti, and G. F. Gensini
Abnormal coronary reserve and left ventricular wall motion during cold pressor test in patients with previous left ventricular ballooning syndrome
Eur. Heart J., August 21, 2009; (2009) ehp325v1.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol IntvHome page
M. H. Shishehbor, S. Madhwal, V. Rajagopal, A. Hsu, P. Kelly, H. S. Gurm, S. R. Kapadia, M. S. Lauer, and E. J. Topol
Impact of Blood Transfusion on Short- and Long-Term Mortality in Patients With ST-Segment Elevation Myocardial Infarction
J. Am. Coll. Cardiol. Intv., January 1, 2009; 2(1): 46 - 53.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
J H Bae, T-G Kwon, D-W Hyun, C S Rihal, and A Lerman
Predictors of slow flow during primary percutaneous coronary intervention: an intravascular ultrasound-virtual histology study
Heart, December 1, 2008; 94(12): 1559 - 1564.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
V. Schachinger, A. Aicher, N. Dobert, R. Rover, J. Diener, S. Fichtlscherer, B. Assmus, F. H. Seeger, C. Menzel, W. Brenner, et al.
Pilot Trial on Determinants of Progenitor Cell Recruitment to the Infarcted Human Myocardium
Circulation, September 30, 2008; 118(14): 1425 - 1432.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Thiele, K. Schindler, J. Friedenberger, I. Eitel, G. Furnau, E. Grebe, S. Erbs, A. Linke, S. Mobius-Winkler, D. Kivelitz, et al.
Intracoronary Compared With Intravenous Bolus Abciximab Application in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: The Randomized Leipzig Immediate Percutaneous Coronary Intervention Abciximab IV Versus IC in ST-Elevation Myocardial Infarction Trial
Circulation, July 1, 2008; 118(1): 49 - 57.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.