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European Heart Journal Advance Access originally published online on March 29, 2007
European Heart Journal 2007 28(8):929-940; doi:10.1093/eurheartj/ehm015
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Coronary sinus blood sampling: an insight into local cardiac pathophysiology and treatment?

Rumi Jaumdally, Chetan Varma, Robert J. Macfadyen and Gregory Y.H. Lip*

Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK

Received 27 November 2006; revised 9 February 2007; accepted 15 February 2007; online publish-ahead-of-print 29 March 2007.

* Corresponding author. Tel: +44 121 507 5080; fax: +44 121 554 4083; E-mail address: g.y.h.lip{at}bham.ac.uk

Atherosclerosis remains the underlying cause of cardiovascular disease and is a dynamic process involving inflammation, haemostasis, endothelial dysfunction, and angiogenesis. Studies of circulating factors from peripheral blood can provide an insight into this pathophysiology but may remain indicative of a more generalized, systemic process. More localized interaction(s) within the heart may be better studied from coronary blood samples. Indeed, an increasing number of prospective studies show good correlation between indices of these processes and clinical outcomes. As local sampling offers a unique way of assessing the local cardiac milieu, this may prove useful in the monitoring of both local/systemic drug therapies and interventional technologies.

Key Words: Coronary sinus • Circulating factors • Myocardial ischaemia


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