European Heart Journal Advance Access originally published online on June 16, 2008
European Heart Journal 2008 29(14):1714-1720; doi:10.1093/eurheartj/ehn248
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The correlation between lipid volume in the target lesion, measured by integrated backscatter intravascular ultrasound, and post-procedural myocardial infarction in patients with elective stent implantation
1 Department of Cardiology, Chubu Rosai Hospital, 1-10-6, Komei, Minato-ku, Nagoya 465-8530, Japan
2 Department of Internal Medicine, Aichi-Gakuin School of Dentistry, Nagoya, Japan
3 Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Received 3 September 2007; revised 16 May 2008; accepted 23 May 2008; online publish-ahead-of-print 16 June 2008.
* Corresponding author. Tel: +81 52 6525511, Fax: +81 52 6533533, Email: uetani{at}med.nagoya-u.ac.jp
See page 1701 for the editorial comment on this article (doi:10.1093/eurheartj/ehn053)
Aims: The aim of this study was to perform quantitative analysis of the plaques of target lesions by integrated backscatter intravascular ultrasound (IB-IVUS) and to investigate the association between these data and the risk of post-procedural myocardial injury after stenting.
Methods and results: One hundred and fourteen consecutive patients who received elective stent implantations following IB-IVUS analysis were enrolled. The volume of each plaque component (lipid, fibrous, and calcified) was calculated for the target lesion. Creatine kinase-MB (CK-MB) and troponin-T (TnT) were also evaluated 18 h after procedure. We defined a post-procedural TnT level higher than three times the normal limit as a post-procedural myocardial injury. Lipid, fibrous, and calcified volumes were greater in patients with myocardial injury than in those without myocardial injury. Lipid and fibrous volumes correlated with post-procedural cardiac biomarkers, and the lipid volume fraction (lipid volume/total plaque volume) also correlated with post-procedural TnT and CK-MB. The fibrous volume fraction for plaques was found to be inversely correlated with post-procedural TnT and CK-MB. Hence, lipid volume and volume fraction were concluded to be independent predictors of post-procedural myocardial injury.
Conclusion: A larger plaque volume and lipid-rich plaque may be indicative of embolic events after stent implantation, resulting in myocardial injury.
Key Words: Intravascular ultrasound • Integrated backscatter intravascular ultrasound • Myocardial injury • Stent
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