European Heart Journal Advance Access originally published online on July 29, 2008
European Heart Journal 2008 29(18):2218-2226; doi:10.1093/eurheartj/ehn336
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High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction
1 Department of Medicine, Atherosclerosis Research Unit, Solna Karolinska Institutet, Stockholm, Sweden
2 Department of Clinical Sciences, Malmö University Hospital, Lund University, Malmö, Sweden
3 Cardiology Unit, Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
4 Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
Received 7 March 2008; revised 24 June 2008; accepted 27 June 2008; online publish-ahead-of-print 29 July 2008.
* Corresponding author: Department of Public Health and Caring Sciences, Institution for Clinical Nutrition and Metabolism, Uppsala Science Park, Uppsala, Sweden. Tel: +46 18 6117975, Fax: +46 18 6117976, Email: per.sjogren{at}pubcare.uu.se
Aims: We examined whether antibodies against peptides 45 and 210 of apoB-100 are related to myocardial infarction (MI) and severity of coronary atherosclerosis.
Methods and results: Three hundred and eighty-seven survivors of a first MI (aged <60 years) and 387 sex- and age-matched controls were characterized in detail. IgG and IgM autoantibodies against native and malondialdehyde (MDA)-modified peptides 45 and 210 of apoB-100 (amino acids 661–680 and 3136–3155) were quantified in plasma and quantitative coronary angiography was performed in 243 patients. Post-infarction patients had significantly lower IgG against the native peptide 210 (IgG-p210nat) and higher IgM against the MDA-modified peptide 210 (IgM-p210MDA) compared with controls, whereas no differences were found for other antibodies. Plasma concentrations of IgG-p210nat, but not IgM-p210MDA, were independently and inversely related to the degree of coronary atherosclerosis in patients. In multiple logistic regression analysis (including established risk indicators), MI risk was 0.55 (95%CI: 0.37–0.81) for individuals in the IgG-p210nat upper quartile compared with the remaining individuals.
Conclusion: Circulating IgG antibodies against the native peptide 210 of apoB-100 are inversely related to the severity of coronary atherosclerosis and associated with lower risk of MI. Epitope 210 of apoB-100 emerges as a target for immunization against atherosclerosis in humans.
Key Words: Myocardial infarction • Coronary atherosclerosis • Angiography • Oxidized LDL • Autoantibodies • apoB-100
Both the authors contributed equally to this work.