Skip Navigation


European Heart Journal Advance Access originally published online on December 12, 2007
European Heart Journal 2008 29(2):198-203; doi:10.1093/eurheartj/ehm525
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
29/2/198    most recent
ehm525v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Pereg, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pereg, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Mild renal dysfunction associated with incident coronary artery disease in young males

David Pereg1, Amir Tirosh2,3, Tzippora Shochat3, David Hasdai for the Metabolic, Lifestyle and Nutrition Assessment in Young adults (MELANY) Investigators4,5,*

1 Department of Internal Medicine A, Meir Medical Center, Kfar Sava, Israel
2 Department of Internal Medicine A, Sheba Medical Center, Tel-Hashomer, Israel
3 Medical Corps Headquarters, Israeli Defense Forces, Tel-Hashomer, Israel
4 Department of Cardiology, Rabin Medical Center, 39 Jabotinsky Street, Petah Tikva 49100, Israel
5 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Received 9 February 2007; revised 22 October 2007; accepted 25 October 2007; online publish-ahead-of-print 12 December 2007.

* Corresponding author. Tel: +972 3 9377130, Fax: +972 3 9249850, Email: dhasdai{at}post.tau.ac.il

Aims: Although impaired renal function is associated with adverse cardiovascular outcomes, it is unknown whether this association exists in young, healthy adults with normal or mildly impaired renal dysfunction.

Methods and results: We calculated the baseline creatinine clearance of young males without antecedent diabetes mellitus, coronary artery disease (CAD), or renal dysfunction, and examined their subsequent diagnosis of CAD, defined as coronary artery diameter stenosis of at least 50% and/or myocardial infarction. The 23 964 males, 32.5 ± 5.9 years old, had a baseline estimated creatinine clearance of 107.9 ± 0.6 mL min–1 per 1.73 m2 (60–150 mL min–1 per 1.73 m2). During a mean follow-up of 3.5 ± 1.9 years, 77 subjects were diagnosed with CAD. After age adjustment, there was a progressive increase in the risk for CAD as the estimated creatinine clearance decreased [hazard ratio (HR) 4.77, 95% confidence interval 3.22–7.06, P < 0.001 for comparison between the fifth and first quintiles]. This association also persisted after further adjustments for conventional and ancillary risk factors for CAD (HR 2.10, 95% confidence interval 1.40–3.14, P < 0.001).

Conclusion: Reduced renal function in the normal to mildly impaired range is independently associated with increased risk for CAD among young, healthy males.

Key Words: Coronary artery disease • Myocardial infarction • Renal failure • Coronary angiography • Creatinine clearance


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
I. Biyik
Mild renal dysfunction associated with incident coronary artery disease in young males (from MELANY Study Investigators)
Eur. Heart J., June 1, 2008; 29(11): 1472 - 1472.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.