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European Heart Journal Advance Access originally published online on December 22, 2007
European Heart Journal 2008 29(3):339-347; doi:10.1093/eurheartj/ehm554
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study

Christophe Tribouilloy*, Dan Rusinaru, Haïfa Mahjoub, Vicky Soulière, Franck Lévy, Marcel Peltier, Michel Slama and Ziad Massy

Department of Cardiovascular Disease, INSERM, ERI 12, Amiens and University Hospital, Amiens 80054, France

Received 22 March 2007; revised 22 October 2007; accepted 29 October 2007; online publish-ahead-of-print 22 December 2007.

* Corresponding author. Tel: +33 3 22 45 58 83, Fax: +33 3 22 45 56 58. Email: tribouilloy.christophe{at}chu-amiens.fr

See page 285 for the editorial comment on this article (doi:10.1093/eurheartj/ehm597)

Aims: This study was designed to identify the characteristics and long-term prognosis of heart failure with preserved ejection fraction (HFPEF) in patients hospitalized for a first episode of HF.

Methods and results: Consecutive patients (n = 799) hospitalized for a first episode of HF during 2000 in the Somme department (France) were recruited. EF was available in 662 (83%) patients, representing the study population. Patients with HFPEF (55.6% of cases) were significantly older, with a high proportion of women. During the 5 year follow-up, 370 patients (56%) died. Patients with HFPEF had a significantly lower 5 year survival than the age- and sex-matched general population (43 vs. 72%). Five year survival rates were not significantly different in patients with preserved and reduced EF (43 vs. 46%; P = 0.95). Both groups had similar relative 5 year survival rates compared with the general population. Multivariable analysis identified age, stroke, chronic obstructive pulmonary disease, cancer, diabetes, low glomerular filtration rate, and hyponatraemia as independent predictors of 5 year mortality in patients with HFPEF.

Conclusions: Heart failure with preserved ejection fraction has a poor prognosis, comparable with that of HF with reduced EF, with a 5 year survival rate after a first episode of 43% and a high excess mortality compared with the general population.

Key Words: Heart failure • Prognosis • Ejection fraction


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