European Heart Journal Advance Access originally published online on February 9, 2008
European Heart Journal 2008 29(5):649-657; doi:10.1093/eurheartj/ehn009
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Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study
1 Department of Medicine II, Johannes Gutenberg-University Mainz, Germany
2 Institute of Medical Biostatistics, Epidemiology, and Informatics, Johannes Gutenberg-University Mainz, Germany
3 Innere Abteilung, Bundeswehrzentralkrankenhaus Koblenz, Koblenz, Germany
4 Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University, Mainz, Germany
Received 20 June 2007; revised 20 December 2007; accepted 7 January 2008; online publish-ahead-of-print 9 February 2008.
* Corresponding authors. Tel: +49 6131 175992, Fax: +49 6131 175691, Email: blankenberg{at}2-med.klinik.uni-mainz.de (S.B.); Tel: +49 6131 175992, Fax: +49 6131 175691, Email: schnabelr{at}gmx.de (R.S.)
Aims: In primary prevention, the adipocytokine adiponectin seems to be protective against diabetes mellitus and cardiovascular disease. Data in patients with manifest coronary artery disease (CAD) are scant stimulating the investigation of the association of adiponectin concentrations and cardiovascular outcome in a prospective CAD cohort.
Methods and results: In 1890 consecutive patients with documented CAD [1130 with stable angina (SAP) and 760 with acute coronary syndrome (ACS)] baseline concentrations of adiponectin were measured by enzyme-linked immuno assay. During a median follow-up of 2.5 years cardiovascular events were registered (cardiovascular deaths 70; non-fatal myocardial infarction 46).
Baseline adiponectin concentrations were similar in patients presenting with SAP [9.03 µg/mL (6.7, 13.45)] or ACS [9.19 µg/mL (6.72, 13.15)], P = 0.779. Kaplan–Meier survival analysis showed a stepwise decrease in event-free survival across quartiles of adiponectin baseline concentration (Plog rank = 0.0188). A similar pattern was observed in both subgroups of patients (SAP P = 0.075 and ACS P = 0.254). In univariate analyses, continuous adiponectin concentration was related to event-free survival in all patients [HR 1.02 (95% confidence interval 1.0–1.04), P = 0.012] as well as in the subgroup of SAP subjects [1.03 (1.01–1.05), P = 0.012]. The relation was less strong in the subgroup presenting with ACS [1.014 (0.99–1.04), P = 0.280]. A correlation of adiponectin with high density cholesterol (r = 0.39) and a negative relation to triglyceride levels (r = –0.22) could be described.
An increase of one interquartile distance in adiponectin concentration was associated with a 1.17-fold risk for future cardiovascular events (P = 0.013), in B-type natriuretic peptide (BNP) it meant a 1.13-fold risk (P < 0.001). In the overall patient group, this risk association remained robust after the adjustment for classical risk factors, clinical presentation and cardiac medication. Only after adjustment for BNP adiponectin lost its independent predictive value.
Conclusion: In contrast to studies including initially healthy individuals, the current prospective study demonstrates that adiponectin is associated with adverse cardiovascular outcome in patients with manifest CAD.
Key Words: Adiponectin • Risk stratification • Coronary artery disease