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European Heart Journal 1982 3(1):2-8;
Copyright © 1982 by the European Society of Cardiology.
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© 1982 by The European Society of Cardiology

Multivariate analysis of exercise ST depression and coronary risk factors in asymptomatic men

C. MANCA, A. L. BARILLI, L. DEI CAS, B. BERNARDINI, R. BOLOGNESI and O. VISIOLI

Università degli Studi di Parma, Cattedra di Cardiologia Parma, Italy

Received 3 March 1981; revised 14 May 1981; .

Abstract

The relationship between exercise ST depression and a set of coronary risk factors was evaluated in 285 asymptomatic men, aged 35–59 years. Only subjects with a normal resting ECG and a systolic blood pressure below 180 mm Hg were included. The following risk factors were considered: age, body mass index, blood pressure, serum lipids and uric acid, basal and after load blood glucose, physical activity and smoking.

Computer analysis of CB5 lead was utilized to study the magnitude of ST responses to a maximal treadmill test. The following ST parameters were evaluated: ST depression at R + 80 ms point (ST2), mean ST depression (STmean) and ST time-voltage integral (STarea). Age, serum cholesterol, blood glucose after load and, to a lesser degree, physical activity have proved to be the risk factors best correlated with exercise ST depression. The multiple regression analysis showed that the global risk factors evaluation explained up to 17% of ST2 variance, 12% of STmean 11% of STarea

In conclusion, our data show that the wide scatter of exercise ST displacement in asymptomatic men is poorly explained by the variability of coronary risk factors.

Key Words: Maximal treadmill exercise • computer • exercise ST depression • coronary risk factors • multiple regression analysis


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