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European Heart Journal 1982 3(2):179-183;
Copyright © 1982 by the European Society of Cardiology.
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© 1982 by The European Society of Cardiology

Exchangeable sodium and saralasin-blocking, plasma renin and aldosterone in pre- and postoperative young patients with aortic coarctation

J. SEHESTED, H. J. KORNERUP and E. B. PEDERSEN

Clinics of Cardiovascular Surgery, Department T and Medicine, Department C, Aarhus Kommunehospital, University of Aarhus 8000 Aarhus C, Denmark

Received 2 July 1981; revised 29 September 1981; .

Request for Reprint to:Jens Sehested, MD, Department of Medicine, Aarhus Amtssygehus University of Aarhus, 8000 AarhusC, Denmark.

Abstract

In a group of eight children (mean age 12 years), all with an uncomplicated aortic coarctation, values of exchangeable sodium, plasma renin activity and plasma aldosterone were determined following administration of furosemide before and on average 138 days after surgical correction. The saralasin test was performed upon six patients before and five after operation.

No statistically significant differences were found between pre- and postoperative values of exchangeable sodium and hormones. There was no correlation between these parameters and blood pressures. Only one patient, on treatment with an anabolic steroid because of Turner's syndrome, showed a depressor response to the pre-operative saralasin test. No reactions were seen in any of the patients after operation. The study does not lend support to the idea of a ‘masked’ renal origin of coarctational hypertension due to an increased fluid volume.

Key Words: Coarctation • exchangeable sodium • saralasin • renin • aldosterone


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