Skip Navigation

European Heart Journal 1982 3(3):203-211;
Copyright © 1982 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by PFISTERER, M.
Right arrow Articles by EMMENEGGER, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PFISTERER, M.
Right arrow Articles by EMMENEGGER, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1982 by The European Society of Cardiology

Non-invasive quantification of exercise-induced changes in regional left ventricular function in normals and patients with one vessel coronary artery disease using radionuclide ventriculography

M. PFISTERER and H. EMMENEGGER

Division of Cardiology, Department of Internal Medicine and Division of Nuclear Medicine, Institute of Radiology, University Hospital Basel, Switzerland

Received 30 June 1981; revised 8 October 1981; .

Requests for reprints to: M. Pfisterer, M.D., Division of Cardiology, University Hospital, CH-4031 Basel, Switzerland.

Abstract

To quantitate changes in regional left ventricular function induced by ischemia or scar, rest and exercise equilibrium radionuclide studies of 26 patients with one vessel coronary artery disease and 12 normal individuals were analysed with a new method for regional ejection fraction determination. A computer algorithm provided observer-independent segmental analysis from a centre of gravity of the left ventricular activity at end-diastole (left anterior oblique projection). Special segments were assigned for anteroseptal, inferoapical and posterolateral areas corresponding to the three main coronary arteries. Reproducibility using an unchanged camera positioning was excellent even for 2 min acquisition studies (r=0.93) and still good after repositioning (r=0.80 to 0.87). In normal areas, regional ejection fraction increased or showed no change during exercise. In contrast, it decreased significantly in regions supplied by stenosed coronary arteries (ischemia) and remained depressed in scar zones. The method proved to be valid for regional changes induced by left anterior descending and left circumflex coronary obstructions, but less for right coronary artery lesions. Global ejection fraction reflected a sum of all regional changes implying that regional analysis should be more sensitive in detecting coronary artery disease.

Key Words: Regional ejection fraction • radionuclide ventriculography • exercise testing • one vessel coronary artery disease • ischemia • scar • reproducibility


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.