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European Heart Journal 1982 3(3):212-222;
Copyright © 1982 by the European Society of Cardiology.
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© 1982 by The European Society of Cardiology

Ventricular response to dynamic exercise and the cold pressor test

J. VOJACEK*, W. J. HANNAN and A. L. MUIR

Departments of Medicine and Medical Physics, Royal Infirmary Edinburgh, Scotland

Received 26 November 1980; revised 28 August 1981; .

Requests for reprint to: Dr A. L. Muir, Department of Medicine, Royal Infirmary, Edinburgh EH3 9YW

Abstract

The ventricular response to stress has been used to identify patients with coronary artery disease, but the most suitable stress test remains in dispute. We compared the ventricular response to supine exercise and the cold pressor test in 10 control subjects and in 12 patients with coronary artery disease. We did not find the previously reported increase of ejection fraction in normal subjects during the cold pressor test, although there was a significant decrease in ejection fraction in patients with coronary artery disease. On supine exercise, normal subjects steadily increased ejection fraction and decreased end-systolic left ventricular volume; patients with coronary artery disease failed to increase ejection fraction and to decrease end-systolic volume. In this study the failure to decrease end-systolic volume during supine exercise appeared the most reliable indicator of impairment of coronary circulation.

Key Words: Cardiac output • ventricular volumes • supine exercise • cold pressor test


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