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European Heart Journal 1982 3(3):276-281;
Copyright © 1982 by the European Society of Cardiology.
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© 1982 by The European Society of Cardiology

Atrial fibrillation induced by atenolol

K. RASMUSSEN, K. ANDERSEN and H. WANG

Section of Cardiology, Department of Medicine, University Hospital of Tromsø Tromsø, Norway

Received 14 May 1981; revised 24 August 1981; .

Requests for reprints to: Dr Knut Rasmussen, Section of Cardiology, Medical Department, Regionsykehuset i Tromsø, 9012 Tromsø, Norway.

Abstract

Twelve patients with a high incidence of paroxysmal atrial fibrillation and conduction abnormalities were investigated electrophysiologically before and after intravenous injection of 2.5 mg atenolol. In accordance with previous studies a significant increase in basic cycle length, sinus node recovery time, sino-atrial conduction time, A-H interval, atrial and A- V nodal refractory periods was found. In addition, six of the 12 patients showed a definite increase in episodes of repetitive atrial responses and atrial fibrillation after atenolol. The underlying electrophysiological mechanism for this increase is unclear. The study indicates that acute use of the drug may exacerbate atrial tachyarrhythmias in susceptible patients.

Key Words: Electrophysiology • atrial fibrillation • beta-adrenergic blockers • atenolol


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