Skip Navigation

European Heart Journal 1982 3(5):433-440;
Copyright © 1982 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by SIMOONS, M. L.
Right arrow Articles by HUGENHOLTZ, P. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SIMOONS, M. L.
Right arrow Articles by HUGENHOLTZ, P. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1982 by The European Society of Cardiology

The effect of intracoronary thrombolysis with streptokinase on myocardial thallium distribution and left ventricular function assessed by blood-pool scintigraphy

M. L. SIMOONS, W. WIJNS, K. BALAKUMARAN, P. W. SERRUYS, M. VAN DEN BRAND, P. FIORETTI, J. H. C. REIBER, P. LIE and P. G. HUGENHOLTZ

Thoraxcenter, Erasmus University and University Hospital Dijkzigt Rotterdam, The Netherlands

Received 24 May 1982; .

Requests for reprints to: M. L Simoons, M.D., Coronary Care Unit, Erasmus University and University Hospital Dijkzigt. P.O. Box 1738. 3000 DR Rotterdam, The Netherlands.

Abstract

In order to evaluate the effect of coronary recanalization in acute myocardial infarction, thallium scintigrams were made on admission in 23 patients in whom thrombolysis was attempted and in 27 patients treated conventionally. The scintigrams were repeated immediately after the procedure or after 3 h in the control group. No significant differences were apparent between the initial thallium uptake in treated patients or controls. Some degree of thallium redistribution occurred in 43 out of 50 patients. The degree of redistribution was greater in patients with open or recanalized arteries (redistribution 35%, s.d. 24% of initial defect) than in patients in whom the artery remained occluded (17%, s.d. 12%). No differences were apparent in six patients between the late scintigrams and a third series of images made after an additional injection of thallium. Global left ventricular function was analysed in 30 patients with anteroseptal infarction and in 35 patients with inferior wall infarction. Ejection fractions were lower in patients with anterior wall infarction. Between one and seven days after admission, ejection fractions were similar in patients with open or occluded arteries in pilot studies and in randomized patients with inferior wall infarction after thrombolysis or conventional treatment. In patients with anterior wall infarction, left ventricular ejection fraction after streptokinase (45%, s.d. 7%) was greater than after conventional treatment (38%, s.d. 12%). Analysis of segmental left ventricular function suggests that this difference is due in part to the improvement of segmental function in the non-infarcted areas. No differences were observed between ejection fractions measured early (1–7 days) or late (10–20 days) after myocardial infarction.

The data show considerable overlap between patients treated with streptokinase and those treated conventionally. Further randomized trials are needed to determine whether thrombolysis in acute myocardial infarction does indeed result in permanent improvement of myocardial function.

Key Words: Myocardial infarction • streptokinase • thallium • left ventricular function


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.