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European Heart Journal 1982 3(5):463-468;
Copyright © 1982 by the European Society of Cardiology.
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© 1982 by The European Society of Cardiology

Effect of coronary artery disease and myocardial ischaemia on transmyocardial platelet aggregability

J. J. DALAL, B. E. GRIFFITHS, M. J. LEWIS*, D. J. SHERIDAN and A. H. HENDERSON

*Departments of Pharmacology Heath Park, Cardiff CF4 4XN, U.K.
Departments of Cardiology, Welsh National School of Medicine Heath Park, Cardiff CF4 4XN, U.K.

Received 21 August 1981; revised 23 November 1981; .

Requests for reprints to: Prof. A. H. Henderson, Department of Cardiology, Welsh National School of Medicine, Heath Park, Cardiff.

Abstract

Twenty-five patients with coronary artery disease and six ‘normal’ subjects were studied during routine catheter investigation for chest pain. In vitro platelet aggregation responses were measured in arterial and coronary sinus blood samples taken at rest and after pacing. Platelet aggregability was found to be increased in coronary sinus blood from patients with coronary artery disease at rest, but it was reduced with pacing. We conclude that platelets are affected by passage through a stenosed coronary artery and that acute myocardial ischaemia exerts an anti-aggregatory effect.

Key Words: Coronary artery disease • myocardial ischaemia • platelet aggregability


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