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European Heart Journal 1982 3(5):481-487;
Copyright © 1982 by the European Society of Cardiology.
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© 1982 by The European Society of Cardiology

Differences in the incidence rate of coronary heart disease between North and South European cohorts of the Seven Countries Study as partially explained by risk factors

S. MARIOTTI*, R. CAPOCACCIA*, G. FARCHI*, A. MENOTTI*, A. VERDECCHIA*, and A. KEYS{dagger}

*Laboratory of Epidemiology and Biostatistics, Istituto Superiore di Sanita' viale Regina Elena 299, 00161 Rome, Italy
{dagger}Laboratory of Physiological Hygiene, University of Minnesota Stadium Gate 27, Minneapolis, Minn. 55455, U.S.A.

Received 5 March 1981; revised 9 December 1981; .

Requests for reprints to: Dr A. Verdecchia, Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore di Sanita', viale Regina Elena 299, 00161 Rome, Italy.

Abstract

The mean values of risk factors have been examined, together with expected incidences of coronary heart disease, in the North and South European cohorts of the Seven Countries Study. The characteristics of the cohorts were markedly different. The differences in incidence which may be attributable to the levels of specific risk factors or groups of factors have been quantified. Serum cholesterol was shown to be the only really important factor in the different incidences. It is suggested that major risk factors exist other than the standard widely-used blood pressure, smoking, cholesterol and age, which accounted for approximately 50% of the different incidence between North and South European cohorts.

Key Words: Differential incidence • risk factors • cohort study • coronary heart disease


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