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European Heart Journal 1982 3(6):546-552;
Copyright © 1982 by the European Society of Cardiology.
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© 1982 by The European Society of Cardiology

Effect of intravenous amiodarone in patients with intraventricular conduction disorders

P. TOUBOUL, G. ATALLAH and G. KIRKORIAN

Hopital Cardiovasculaire et Pneumologique Louis Pradel BP Lyon Montchat, 69394 Lyon Cedex 3, France

Received 26 October 1981; revised 21 December 1981; .

Abstract

Using His bundle recordings and stimulation techniques, the electrical effects of amiodarone (5 mg/kg intravenously) were assessed in 12 patients aged 34–80 years (mean 65) exhibiting in sinus rhythm, intraventricular conduction disturbances. Bundle branch block was present in 10 patients: left bundle branch block in three patients, right bundle branch block in three, bilateral bundle branch block in four. All the patients had a long H-V interval (65–80 ms; mean 71). As has been previously reported, amiodarone slowed the sinus rate, prolonged the QT interval, increased the atrial effective refractory period and depressed A-V nodal conduction. Despite the presence of advanced conduction disturbances within the His-Purkinje system, amiodarone did not alter the H-V interval in 11 patients and increased it in one by only 5 ms. Thus, clinically, the use of amiodarone in patients with bundle branch block should be safe.

Key Words: Amiodarone • bundle branch block • refractory periods


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