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European Heart Journal 1982 3(6):553-563;
Copyright © 1982 by the European Society of Cardiology.
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© 1982 by The European Society of Cardiology

Intracardiac electrophysiological study of disopyramide in intact and chemically sympathectomized dogs*

C. GUIMOND, C. VASSEUR, D. GODIN, B. PELLETIER, A. R. LEBLANC and R. NADEAU

Centre de recherche, Hôpital du Sacré-Coeur, Montréal and Department of Physiology, Faculty of Medicine, Université de Montréal Québec, Canada

Received 25 August 1981; revised 17 November 1981; .

Requests for reprints to: Dr Claude Guimond, Centre de recherche, Hopital du Sacre-Coeur, 5400 boul. Gouin ouest, Montreal, Quebec, Canada H4J 1C5.

Abstract

The influence of sympathetic tone on the action of disopyramide was assessed by studying the electrophysiological changes which followed the intravenous injection of 4 mg/kg of disopyramide into anesthetized dogs chemically sympathectomized with 6-hydroxydopamine. Atrial and ventricular pacing, together with recordings of the His bundle electrogram allowed assessment of the sinus node function, measurement of the atrioventricular and ventricular conduction intervals, and the detection of the supernormal conduction phenomenon. The duration of atrial (MAPa) and ventricular (MAPv) monophasic action potentials recorded by suction electrodes and their relation to the effective (ERP) and functional (FRP) refractory periods were measured in the atria and ventricles; the ERP/MAP ratio was also measured. The results show that the lengthening of the basic sinus cycle length and of the atrial and ventricular MAP, ERP and FRP observed after disopyramide is not only masked by the well-known anticholinergic effect of this agent but also by the degree of sympathetic tone. The integrity of the sympathetic nervous system is a requirement for the presence of effective antiarrhythmic effects of disopyramide in the ventricle.

Key Words: Electrophysiology • 6-hydroxydopamine • disopyramide • monophasic action potentials


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