Skip Navigation


European Heart Journal Advance Access originally published online on May 27, 2009
European Heart Journal 2009 30(16):2003-2010; doi:10.1093/eurheartj/ehp152
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
30/16/2003    most recent
ehp152v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Leonardi, S.
Right arrow Articles by Arbustini, E.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leonardi, S.
Right arrow Articles by Arbustini, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Usefulness of cardiac magnetic resonance in assessing the risk of ventricular arrhythmias and sudden death in patients with hypertrophic cardiomyopathy

Sergio Leonardi1, Claudia Raineri1,*, Gaetano M. De Ferrari1, Stefano Ghio1, Laura Scelsi1, Michele Pasotti2, Marilena Tagliani2, Adele Valentini3, Roberto Dore3, Arturo Raisaro1 and Eloisa Arbustini2

1 Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia (PV), Italy
2 Centre for Inherited Cardiovascular Diseases, IRCCS Foundation, Policlinico San Matteo, Pavia (PV), Italy
3 Institute of Radiology, Fondazione IRCCS Policlinico San Matteo, Pavia (PV), Italy

Received 1 August 2008; revised 3 February 2009; accepted 17 March 2009; online publish-ahead-of-print 27 May 2009.

* Corresponding author. Tel: +39 0 382501034, Fax: +39 0 382503161, Email: c.raineri{at}smatteo.pv.it

Aims: To assess the relationship between cardiovascular magnetic resonance (CMR) parameters and both spontaneous ventricular tachycardia (VT) and risk of sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) patients.

Methods and results: One hundred and eight consecutive HCM patients (mean age 42 ± 15 years, 76% males) underwent CMR evaluation and risk assessment. Delayed contrast enhancement (DCE) was quantified with a specifically designed score. Endpoints were either the presence of clinical VT/ventricular fibrillation (VF) or of acknowledged risk factors for SCD. Compared to patients without arrhythmia, those with VT/VF (n = 33) had a higher DCE score [median 8 (2–13) vs. 11 (6–20); P = 0.01]; DCE score was also the only independent predictor of VT/VF in the multivariable model. DCE score [median 6 (1–10.5) vs. 12 (6–18); P = 0.001], mean and maximal left ventricular (LV) wall thickness (MaxLVWT), as well as LV mass index were significantly greater among patients at risk for SCD (n = 51) compared with the remaining 57 patients at low risk. DCE score and MaxLVWT were independent predictors of SCD risk.

Conclusion: In HCM patients several CMR parameters are associated with risk for SCD. A semi-quantitative index of DCE is a significant multivariable predictor of both clinical VT/VF and of risk for SCD and may contribute to risk assessment in borderline or controversial cases.

Key Words: Cardiovascular magnetic resonance • Sudden cardiac death • Hypertrophic cardiomyopathy • Ventricular tachycardia/fibrillation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur J Heart FailHome page
S. Ghio, M. Revera, F. Mori, C. Klersy, A. Raisaro, C. Raineri, A. Serio, M. Pasotti, and L. O. Visconti
Regional abnormalities of myocardial deformation in patients with hypertrophic cardiomyopathy: correlations with delayed enhancement in cardiac magnetic resonance
Eur J Heart Fail, October 1, 2009; 11(10): 952 - 957.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.