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European Heart Journal Advance Access originally published online on January 27, 2009
European Heart Journal 2009 30(6):731-739; doi:10.1093/eurheartj/ehn596
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Tissue Doppler echocardiography in persons with hypertension, diabetes, or ischaemic heart disease: the Copenhagen City Heart Study

Rasmus Mogelvang1,2,*, Peter Sogaard2, Sune A. Pedersen2, Niels T. Olsen2, Peter Schnohr1 and Jan S. Jensen1,2

1 Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
2 Department of Cardiology, Gentofte Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Received 15 April 2008; revised 26 October 2008; accepted 17 December 2008; online publish-ahead-of-print 27 January 2009.

* Corresponding author: Department of Cardiology, Gentofte Hospital Post 4210, 65 Niels Andersens Vej, DK-2900 Hellerup, Denmark. Tel: +45 26826407, Fax: +45 39777381, Email: Rasmus.Mogelvang{at}get2net.dk; rasmoe01{at}geh.regionh.dk

See page 642 for the editorial comment on this article (doi:10.1093/eurheartj/ehp067)

Aims: To test the hypothesis that echocardiographic tissue Doppler imaging (TDI) reveals reduced myocardial function in hypertension, diabetes, and ischaemic heart disease (IHD) in the general population.

Methods and results: Within a large, community-based population study, cardiac function was evaluated in 1036 participants by both conventional echocardiography and colour TDI. Peak systolic (s') and early diastolic (e') velocities, longitudinal displacement (LD), and the ratio of mitral inflow E-wave to e' (E/e') were measured. TDI revealed significantly impaired parameters of systolic and diastolic cardiac function in hypertension [n = 345; LD 10.1 (±standard deviation, SD 2.0 mm), P < 0.001; E/e' 12.4 (x÷SD 1.4), P < 0.001], diabetes [n = 65; LD 9.8 (±SD 2.2 mm), P < 0.001; E/e' 12.7 (x÷SD 1.5), P < 0.001], and IHD [n = 93; LD 9.4 (±SD 2.5 mm), P < 0.001; E/e' 13.0 (x÷SD 1.5), P < 0.001] compared with controls [n = 533; LD 11.4 (±SD 2.0 mm); E/e' 9.0 (x÷SD 1.3)]. This pattern remained significant after adjusting for age, sex, body mass index, heart rate, and the results of conventional echocardiography.

Conclusion: In the general population, persons with hypertension, diabetes, or IHD have impaired cardiac function by TDI independently of the result of conventional echocardiography.

Key Words: Echocardiography • Tissue Doppler imaging • Population • Ischaemic heart disease • Hypertension • Diabetes mellitus


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