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European Heart Journal 1983 4(1):59-63;
Copyright © 1983 by the European Society of Cardiology.
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© 1983, by the European Society of Cardiology

Reversible alteration of myocardial function in gestational diabetes

G. CELLINA, G. LO CICERO, A. BRINA and A. ZANCHETTI*,

Istituti Clinici di Perfezionamento, Servizio di Cardiologia, Ospedale Maggiore Milan Italy
*Clinica Medica IV, Università di Milano and Ospedale Maggiore Milan, Italy

Received 28 May 1981; revised 18 January 1982; .

Requests for reprints to: Alberti Zanchetti, 1st, Fisiologia Clinica e Ipertensione, Ospedale Maggiore, Via F. Sforza 35, 20122 Milano, Italy

Abstract

Left ventricular function was evaluated in 24 women who developed impaired glucose tolerance only during their pregnancy, i.e. patients with gestational diabetes. The results were compared with those of 25 normal pregnant women and with those of 17 pregnant women with clinical diabetes. The method of systolic time interval was applied. At the third trimester of pregnancy, both the women with overt diabetes and those with gestational diabetes when compared with normal pregnants subjects, had a more prolonged preejection period (PEP) and a shorter left ventricular ejection time (LVET) and, consequently, a higher PEP/LVET ratio. Five weeks after delivery, abnormalities of systolic time intervals presisted in patients with clinical diabetes, but there were no differences at this time between patients with gestational diabetes and those in the control group. It is concluded that when a cardiac load is superimposed on patients who develop diabetes only under conditions of stress, as in pregnancy (gestational diabetes), abnormalities of myocardial function appear, which revert to normal when the stressful event is removed.

Key Words: Diabetes • myocardial performance • systolic time intervals


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