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European Heart Journal 1983 4(10):699-705;
Copyright © 1983 by the European Society of Cardiology.
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© 1983, by the European Society of Cardiology

The systemic and coronary haemodynamic effects of felodipine in patients with coronary heart disease

A. C. TWEDDEL, G. JOHNSSON, T. H. PRINGLE, R. G. MURRAY and I. HUTTON

University Department of Medical Cardiology, Royal Infirmary Glasgow

Received 16 September 1982; revised 7 January 1983; .

Requests for reprints to: Dr I. Hutton, M.D., University Department of Medical Cardiology, University Tower, 10, Alexandra Parade, Glasgow G31 2ES.

Abstract

The cardiovascular effects of felodipine, a new arteriolar vasodilator, were studied in 22 patients with coronary heart disease. There were significant falls in blood pressure and systemic vascular resistance of 16 and 38% respectively (P = 0.001), thus affecting after-load. Cardiac index and stroke index increased by 35 and 12% respectively. There was reflex tachycardia-from 75 ±3 to 85 ±3 b.p.m. (P =0.005). Coronary sinus blood /low increased from 134±9 to 191 ±17 ml/min (P<0.005) and myocardial arterio- venous oxygen difference narrowed from 12.l±0.5 to 9.0±0.4 vols% (P<0.001) indicating less oxygen usage. With the heart rate held constant by atrial pacing, cardiac index and stroke index increased by 30 and 26% (P<0.001), whilst systolic blood pressure and systemic vascular resistance fell by 20 and 29% (P<0.001). This would suggest that the improved haemodynamics were largely secondary to after-load reduction.

Key Words: Felodipine • arteriolar vasodilator • coronary and systemic haemodynamics • atrial pacing


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