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European Heart Journal 1983 4(10):728-732;
Copyright © 1983 by the European Society of Cardiology.
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© 1983, by the European Society of Cardiology

Electrophysiological effects of prenalterol on the cardiac conduction system

U. DAHLSTRÖM and C. LASSVIK{dagger}

Division of Cardiology, Departments of Medicine, University Hospital S-581 85 Linköping, Sweden
{dagger}Division of Cardiology, Clinical Physiology, University Hospital S-581 85 Linköping, Sweden

Received 5 October 1982; revised 30 December 1982; .

Requests for reprints to: Dr V. Dahlström, Division of Cardiology, Departments of Medicine and Clinical Physiology, University Hospital. S-581 85 Linköping, Sweden

Abstract

The electrophysiological effects of prenalterol, a new beta-receptor agonist, in a dose of 100 µg/kg body weight given intravenously for 5 min, were studied in 13 patients with signs of sinus node dysfunction and/or conduction defects within or distal to the atrioventricular (AV) node.

In nine patients with signs of sinus node dysfunction a significant reduction was found in corrected sinus node recovery time, on an average by 1955±640ms (–61%, P<0.05) and in atrial refractoriness, by 61 ±21 ms (–20%, P<0.05). Similar but insignificant changes were also seen in the four patients with normal sinus node function. In eight patients with AV nodal dysfunction, a significant increase was found in the Wenckebach point, by 51±10b.p.m (+52%. P<0.01) and a decrease in the AH interval, by 23±9ms(–14%, P<0.05). AV nodal refractoriness tended to decrease by 115±58 ms(–24%, NS). Similar changes were found in the five patients with normal AV conduction. Heart rate increased in all 13 patients, on an average by 28±5 b.p.m. (+44%, P<0.001) and systolic blood pressure by 18±8 mmHg (+13% P0.01).

In conclusion, prenalterol increased sinus node automaticity and atrial and AV nodal conductivity, but did not improve infranodal conduction. Thus, the drug might be useful in the treatment of patients with sinus node dysfunction as well as in patients with spontaneous or induced atrioventricular conduction abnormalities.

Key Words: Prenalterol • electrophysiology • conduction defects


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