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European Heart Journal 1983 4(12):889-893;
Copyright © 1983 by the European Society of Cardiology.
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© 1983, by the European Society of Cardiology

Ventricular arrhythmias associated with lidoflazine: side-effects observed in a randomized trial

S. P. HANLEY and J. R. HAMPTON

Department of Medicine, University Hospital, Queen's Medical Centre Nottingham NG7 2UH, U.K.

Received 6 February 1983; revised 29 June 1983; .

Requests for reprints to Dr S. P. Hanley, Department of Medicine, D Floor, South Block, University Hospital, Queen's Medical Centre. Nottingham NG7 2UH.

Abstract

Twenty-four patients received either propranolol, lidoflazine (Clinium), or propranolol/lidoflazine combinations in a study designed to evaluate the effect of these drugs in angina pectoris. Five patients developed ventricular tachycardia when receiving either lidoflazine or lidoflazine and propranolol in combination; one of these patients died. In addition, one patient died suddenly while being treated with propranolol alone. Lidoflazine therapy was associated with a significant prolongation of the QT interval of the electrocardiogram. Lidoflazine either alone or in combination with propranolol, appears to induce ventricular tachycardia.

Key Words: Angina • exercise testing • lidoflazine • propranolol • ventricular tachycardia


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